Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip (Adv. Sci. 14/2022)

Organ‐on‐a‐Chip A microfluidic organ‐on‐a‐chip model of the human lymphoid follicle that recapitulates vaccination responses in vitro. Blood‐derived cells self assemble into germinal centers in a matrix gel in the lower channel when nutrient medium is flowed through the upper channel. Antigen‐specif...

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Detalles Bibliográficos
Autores principales: Goyal, Girija, Prabhala, Pranav, Mahajan, Gautam, Bausk, Bruce, Gilboa, Tal, Xie, Liangxia, Zhai, Yunhao, Lazarovits, Roey, Mansour, Adam, Kim, Min Sun, Patil, Aditya, Curran, Danielle, Long, Jaclyn M., Sharma, Sanjay, Junaid, Abidemi, Cohen, Limor, Ferrante, Thomas C., Levy, Oren, Prantil‐Baun, Rachelle, Walt, David R., Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109052/
http://dx.doi.org/10.1002/advs.202270090
Descripción
Sumario:Organ‐on‐a‐Chip A microfluidic organ‐on‐a‐chip model of the human lymphoid follicle that recapitulates vaccination responses in vitro. Blood‐derived cells self assemble into germinal centers in a matrix gel in the lower channel when nutrient medium is flowed through the upper channel. Antigen‐specific antibodies and cytokines are secreted in response to seasonal influenza vaccination that mirror responses observed in patients. More details can be found in article number 2103241 by Donald E. Ingber and co‐workers. [Image: see text]

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