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Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome

BACKGROUND: Immune checkpoint inhibitors (ICI) can lead to long-term responses in patients with metastatic melanoma. Still many patients with melanoma are intrinsically resistant or acquire secondary resistance. Previous studies have used primary or metastatic tumor tissue for biomarker assessment....

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Detalles Bibliográficos
Autores principales:	Gorris, Mark A J, van der Woude, Lieke L, Kroeze, Leonie I, Bol, Kalijn, Verrijp, Kiek, Amir, Avital L, Meek, Jelena, Textor, Johannes, Figdor, Carl G, de Vries, I Jolanda M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109111/ https://www.ncbi.nlm.nih.gov/pubmed/35550553 http://dx.doi.org/10.1136/jitc-2021-004329

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