Tissue-resident memory T cells from a metastatic vaginal melanoma patient are tumor-responsive T cells and increase after anti-PD-1 treatment

BACKGROUND: Vaginal melanoma (VM) is a rare cancer and has a poor response to immune checkpoint blockade (ICB). CD8(+)Tissue Resident Memory (TRM) T cells proliferate in response to ICB and correlate with longer survival in metastatic cutaneous melanoma. However, their capacity to respond to VM and...

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Detalles Bibliográficos
Autores principales: Pizzolla, Angela, Keam, Simon Paul, Vergara, Ismael A, Caramia, Franco, Thio, Niko, Wang, Minyu, Kocovski, Nikolce, Tantalo, Daniela, Jabbari, Jafar, Au-Yeung, George, Sandhu, Shahneen, Gyorki, David E, Weppler, Alison, Perdicchio, Maurizio, McArthur, Grant A, Papenfuss, Anthony T, Neeson, Paul Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109124/
https://www.ncbi.nlm.nih.gov/pubmed/35550554
http://dx.doi.org/10.1136/jitc-2022-004574

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