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PPAR-gamma Fun(gi) With Prostaglandin
In our recent publication, we show for the first time that the fungal pathogen Cryptococcus neoformans is able to manipulate host cells by producing eicosanoids that mimic those found in the host. Using complementary in vivo zebrafish and in vitro macrophage cell culture models of Cryptococcus infec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109145/ https://www.ncbi.nlm.nih.gov/pubmed/35582457 http://dx.doi.org/10.1177/1550762919899641 |
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author | Evans, Robert J. Johnston, Simon A. |
author_facet | Evans, Robert J. Johnston, Simon A. |
author_sort | Evans, Robert J. |
collection | PubMed |
description | In our recent publication, we show for the first time that the fungal pathogen Cryptococcus neoformans is able to manipulate host cells by producing eicosanoids that mimic those found in the host. Using complementary in vivo zebrafish and in vitro macrophage cell culture models of Cryptococcus infection, we found that these eicosanoids manipulate host innate immune cells by activating the host receptor PPAR-gamma which is an important regulator of macrophage inflammatory phenotypes. We initially identified PGE2 as the eicosanoid species responsible for this effect; however, we later found that a derivative of PGE2—15-keto-PGE(2)—was ultimately responsible and that this eicosanoid acted as a partial agonist to PPAR-gamma. In this commentary, we will discuss some of the concepts and conclusions in our original publication and expand on their implications and future directions. |
format | Online Article Text |
id | pubmed-9109145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91091452022-05-16 PPAR-gamma Fun(gi) With Prostaglandin Evans, Robert J. Johnston, Simon A. Nucl Recept Signal Commentary In our recent publication, we show for the first time that the fungal pathogen Cryptococcus neoformans is able to manipulate host cells by producing eicosanoids that mimic those found in the host. Using complementary in vivo zebrafish and in vitro macrophage cell culture models of Cryptococcus infection, we found that these eicosanoids manipulate host innate immune cells by activating the host receptor PPAR-gamma which is an important regulator of macrophage inflammatory phenotypes. We initially identified PGE2 as the eicosanoid species responsible for this effect; however, we later found that a derivative of PGE2—15-keto-PGE(2)—was ultimately responsible and that this eicosanoid acted as a partial agonist to PPAR-gamma. In this commentary, we will discuss some of the concepts and conclusions in our original publication and expand on their implications and future directions. SAGE Publications 2020-01-23 /pmc/articles/PMC9109145/ /pubmed/35582457 http://dx.doi.org/10.1177/1550762919899641 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Commentary Evans, Robert J. Johnston, Simon A. PPAR-gamma Fun(gi) With Prostaglandin |
title | PPAR-gamma Fun(gi) With Prostaglandin |
title_full | PPAR-gamma Fun(gi) With Prostaglandin |
title_fullStr | PPAR-gamma Fun(gi) With Prostaglandin |
title_full_unstemmed | PPAR-gamma Fun(gi) With Prostaglandin |
title_short | PPAR-gamma Fun(gi) With Prostaglandin |
title_sort | ppar-gamma fun(gi) with prostaglandin |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109145/ https://www.ncbi.nlm.nih.gov/pubmed/35582457 http://dx.doi.org/10.1177/1550762919899641 |
work_keys_str_mv | AT evansrobertj ppargammafungiwithprostaglandin AT johnstonsimona ppargammafungiwithprostaglandin |