Tranilast for advanced heart failure in patients with muscular dystrophy: a single-arm, open-label, multicenter study

BACKGROUND: The transient receptor potential cation channel subfamily V member 2 (TRPV2) is a stretch-sensitive calcium channel. TRPV2 overexpression in the sarcolemma of skeletal and cardiac myocytes causes calcium influx into the cytoplasm, which triggers myocyte degeneration. In animal models of...

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Detalles Bibliográficos
Autores principales: Matsumura, Tsuyoshi, Hashimoto, Hiroya, Sekimizu, Masahiro, Saito, Akiko M., Motoyoshi, Yasufumi, Nakamura, Akinori, Kuru, Satoshi, Fukudome, Takayasu, Segawa, Kazuhiko, Takahashi, Toshiaki, Tamura, Takuhisa, Komori, Tetsuo, Watanabe, Chigusa, Asakura, Masanori, Kimura, Koichi, Iwata, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109199/
https://www.ncbi.nlm.nih.gov/pubmed/35578298
http://dx.doi.org/10.1186/s13023-022-02352-3

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