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An increase in spontaneous activity mediates visual habituation
The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during vis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109218/ https://www.ncbi.nlm.nih.gov/pubmed/35476991 http://dx.doi.org/10.1016/j.celrep.2022.110751 |
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author | Miller, Jae-eun Kang Miller, Bradley R. O’Neil, Darik A. Yuste, Rafael |
author_facet | Miller, Jae-eun Kang Miller, Bradley R. O’Neil, Darik A. Yuste, Rafael |
author_sort | Miller, Jae-eun Kang |
collection | PubMed |
description | The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during visual habituation to a specific oriented stimulus. We find that, during habituation, spontaneous activity increases in neurons across the full range of orientation selectivity, eventually matching that of evoked levels. This increase in spontaneous activity robustly correlates with the degree of habituation. Moreover, boosting spontaneous activity with two-photon optogenetic stimulation to the levels of visually evoked activity accelerates habituation. Our study shows that cortical spontaneous activity is linked to habituation, and we propose that habituation unfolds by minimizing the difference between spontaneous and stimulus-evoked activity levels. We conclude that baseline spontaneous activity could gate incoming sensory information to the cortex based on the learned experience of the animal. |
format | Online Article Text |
id | pubmed-9109218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-91092182022-05-16 An increase in spontaneous activity mediates visual habituation Miller, Jae-eun Kang Miller, Bradley R. O’Neil, Darik A. Yuste, Rafael Cell Rep Article The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during visual habituation to a specific oriented stimulus. We find that, during habituation, spontaneous activity increases in neurons across the full range of orientation selectivity, eventually matching that of evoked levels. This increase in spontaneous activity robustly correlates with the degree of habituation. Moreover, boosting spontaneous activity with two-photon optogenetic stimulation to the levels of visually evoked activity accelerates habituation. Our study shows that cortical spontaneous activity is linked to habituation, and we propose that habituation unfolds by minimizing the difference between spontaneous and stimulus-evoked activity levels. We conclude that baseline spontaneous activity could gate incoming sensory information to the cortex based on the learned experience of the animal. 2022-04-26 /pmc/articles/PMC9109218/ /pubmed/35476991 http://dx.doi.org/10.1016/j.celrep.2022.110751 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Miller, Jae-eun Kang Miller, Bradley R. O’Neil, Darik A. Yuste, Rafael An increase in spontaneous activity mediates visual habituation |
title | An increase in spontaneous activity mediates visual habituation |
title_full | An increase in spontaneous activity mediates visual habituation |
title_fullStr | An increase in spontaneous activity mediates visual habituation |
title_full_unstemmed | An increase in spontaneous activity mediates visual habituation |
title_short | An increase in spontaneous activity mediates visual habituation |
title_sort | increase in spontaneous activity mediates visual habituation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109218/ https://www.ncbi.nlm.nih.gov/pubmed/35476991 http://dx.doi.org/10.1016/j.celrep.2022.110751 |
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