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An increase in spontaneous activity mediates visual habituation

The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during vis...

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Detalles Bibliográficos
Autores principales: Miller, Jae-eun Kang, Miller, Bradley R., O’Neil, Darik A., Yuste, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109218/
https://www.ncbi.nlm.nih.gov/pubmed/35476991
http://dx.doi.org/10.1016/j.celrep.2022.110751
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author Miller, Jae-eun Kang
Miller, Bradley R.
O’Neil, Darik A.
Yuste, Rafael
author_facet Miller, Jae-eun Kang
Miller, Bradley R.
O’Neil, Darik A.
Yuste, Rafael
author_sort Miller, Jae-eun Kang
collection PubMed
description The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during visual habituation to a specific oriented stimulus. We find that, during habituation, spontaneous activity increases in neurons across the full range of orientation selectivity, eventually matching that of evoked levels. This increase in spontaneous activity robustly correlates with the degree of habituation. Moreover, boosting spontaneous activity with two-photon optogenetic stimulation to the levels of visually evoked activity accelerates habituation. Our study shows that cortical spontaneous activity is linked to habituation, and we propose that habituation unfolds by minimizing the difference between spontaneous and stimulus-evoked activity levels. We conclude that baseline spontaneous activity could gate incoming sensory information to the cortex based on the learned experience of the animal.
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spelling pubmed-91092182022-05-16 An increase in spontaneous activity mediates visual habituation Miller, Jae-eun Kang Miller, Bradley R. O’Neil, Darik A. Yuste, Rafael Cell Rep Article The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during visual habituation to a specific oriented stimulus. We find that, during habituation, spontaneous activity increases in neurons across the full range of orientation selectivity, eventually matching that of evoked levels. This increase in spontaneous activity robustly correlates with the degree of habituation. Moreover, boosting spontaneous activity with two-photon optogenetic stimulation to the levels of visually evoked activity accelerates habituation. Our study shows that cortical spontaneous activity is linked to habituation, and we propose that habituation unfolds by minimizing the difference between spontaneous and stimulus-evoked activity levels. We conclude that baseline spontaneous activity could gate incoming sensory information to the cortex based on the learned experience of the animal. 2022-04-26 /pmc/articles/PMC9109218/ /pubmed/35476991 http://dx.doi.org/10.1016/j.celrep.2022.110751 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Miller, Jae-eun Kang
Miller, Bradley R.
O’Neil, Darik A.
Yuste, Rafael
An increase in spontaneous activity mediates visual habituation
title An increase in spontaneous activity mediates visual habituation
title_full An increase in spontaneous activity mediates visual habituation
title_fullStr An increase in spontaneous activity mediates visual habituation
title_full_unstemmed An increase in spontaneous activity mediates visual habituation
title_short An increase in spontaneous activity mediates visual habituation
title_sort increase in spontaneous activity mediates visual habituation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109218/
https://www.ncbi.nlm.nih.gov/pubmed/35476991
http://dx.doi.org/10.1016/j.celrep.2022.110751
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