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Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series

BACKGROUND: A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case series is to describe atypical chorioretinal lesions observ...

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Autores principales: Park, Shin Ae, Sledge, Dodd, Monahan, Colleen F., Teixeira, Leandro, Boyd, Ryan, Freeman, Katie, Koehl, Kristin, Harman, Christine, Munoz, Kirk, Occelli, Laurence M., Pirie, Chris G., Davidson, Harriet, Petersen-Jones, Simon, Komáromy, András M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109312/
https://www.ncbi.nlm.nih.gov/pubmed/35578341
http://dx.doi.org/10.1186/s12917-022-03259-8
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author Park, Shin Ae
Sledge, Dodd
Monahan, Colleen F.
Teixeira, Leandro
Boyd, Ryan
Freeman, Katie
Koehl, Kristin
Harman, Christine
Munoz, Kirk
Occelli, Laurence M.
Pirie, Chris G.
Davidson, Harriet
Petersen-Jones, Simon
Komáromy, András M.
author_facet Park, Shin Ae
Sledge, Dodd
Monahan, Colleen F.
Teixeira, Leandro
Boyd, Ryan
Freeman, Katie
Koehl, Kristin
Harman, Christine
Munoz, Kirk
Occelli, Laurence M.
Pirie, Chris G.
Davidson, Harriet
Petersen-Jones, Simon
Komáromy, András M.
author_sort Park, Shin Ae
collection PubMed
description BACKGROUND: A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case series is to describe atypical chorioretinal lesions observed in dogs with primary angle-closure glaucoma (PACG). CASE PRESENTATION: Two spayed-female Siberian Huskies (3- and 4-year-old) and one Siberian Husky/Australian Shepherd mixed breed dog (11-month-old) that had multifocal depigmented retinal lesions and PACG were included. Procedures: Ophthalmic examination, gross, and histopathologic examination findings are described. One of the dogs underwent further clinical diagnostics. Advanced clinical diagnostics on the fellow, presumed to be non-glaucomatous eye of a dog revealed: pectinate ligament dysplasia by gonioscopy, retinal thinning in the depigmented area and wedge shaped retinal thinning with delayed choroidal vascular perfusion by optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein and indocyanine green angiography. Quantifiable maze testing for the same eye revealed mild nyctalopia but the full-field electroretinogram showed no generalized decrease of retinal function. Genetic testing for mutations within the retinitis pigmentosa GTPase regulator gene causing X-linked progressive retinal atrophy in Siberian Huskies was negative. Histopathologic evaluations on enucleated eyes in two dogs confirmed goniodysgenesis, PACG with optic nerve head cupping, and diffuse inner retinal atrophy. In addition, segmental profound retinal atrophy, loss of retinal pigment epithelium, and adhesion of the retina to Bruch’s membrane was observed and coincided with multifocal depigmented lesions noted on fundic examination. CONCLUSIONS: To our knowledge, this is the first case series with clinical and histopathologic data of chorioretinal lesions, most likely caused by severely impaired choroidal perfusion. Further studies are warranted to elucidate the etiology and pathophysiology, including its possible association with PACG.
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spelling pubmed-91093122022-05-17 Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series Park, Shin Ae Sledge, Dodd Monahan, Colleen F. Teixeira, Leandro Boyd, Ryan Freeman, Katie Koehl, Kristin Harman, Christine Munoz, Kirk Occelli, Laurence M. Pirie, Chris G. Davidson, Harriet Petersen-Jones, Simon Komáromy, András M. BMC Vet Res Case Report BACKGROUND: A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case series is to describe atypical chorioretinal lesions observed in dogs with primary angle-closure glaucoma (PACG). CASE PRESENTATION: Two spayed-female Siberian Huskies (3- and 4-year-old) and one Siberian Husky/Australian Shepherd mixed breed dog (11-month-old) that had multifocal depigmented retinal lesions and PACG were included. Procedures: Ophthalmic examination, gross, and histopathologic examination findings are described. One of the dogs underwent further clinical diagnostics. Advanced clinical diagnostics on the fellow, presumed to be non-glaucomatous eye of a dog revealed: pectinate ligament dysplasia by gonioscopy, retinal thinning in the depigmented area and wedge shaped retinal thinning with delayed choroidal vascular perfusion by optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein and indocyanine green angiography. Quantifiable maze testing for the same eye revealed mild nyctalopia but the full-field electroretinogram showed no generalized decrease of retinal function. Genetic testing for mutations within the retinitis pigmentosa GTPase regulator gene causing X-linked progressive retinal atrophy in Siberian Huskies was negative. Histopathologic evaluations on enucleated eyes in two dogs confirmed goniodysgenesis, PACG with optic nerve head cupping, and diffuse inner retinal atrophy. In addition, segmental profound retinal atrophy, loss of retinal pigment epithelium, and adhesion of the retina to Bruch’s membrane was observed and coincided with multifocal depigmented lesions noted on fundic examination. CONCLUSIONS: To our knowledge, this is the first case series with clinical and histopathologic data of chorioretinal lesions, most likely caused by severely impaired choroidal perfusion. Further studies are warranted to elucidate the etiology and pathophysiology, including its possible association with PACG. BioMed Central 2022-05-16 /pmc/articles/PMC9109312/ /pubmed/35578341 http://dx.doi.org/10.1186/s12917-022-03259-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Park, Shin Ae
Sledge, Dodd
Monahan, Colleen F.
Teixeira, Leandro
Boyd, Ryan
Freeman, Katie
Koehl, Kristin
Harman, Christine
Munoz, Kirk
Occelli, Laurence M.
Pirie, Chris G.
Davidson, Harriet
Petersen-Jones, Simon
Komáromy, András M.
Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title_full Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title_fullStr Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title_full_unstemmed Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title_short Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series
title_sort atypical chorioretinal lesions in siberian husky dogs with primary angle-closure glaucoma: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109312/
https://www.ncbi.nlm.nih.gov/pubmed/35578341
http://dx.doi.org/10.1186/s12917-022-03259-8
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