ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis

OBJECTIVES: To screen and verify differential genes affecting the prognosis of breast cancer. METHODS: Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T an...

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Autores principales: Xiao, Yu, Deng, Zhiqin, Li, Yongshen, Wei, Baoting, Chen, Xiaoqiang, Zhao, Zhe, Xiu, Yingjie, Hu, Meifang, Alahdal, Murad, Deng, Zhenhan, Wang, Daping, Liu, Jianquan, Li, Wencui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109316/
https://www.ncbi.nlm.nih.gov/pubmed/35578283
http://dx.doi.org/10.1186/s12935-022-02611-0
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author Xiao, Yu
Deng, Zhiqin
Li, Yongshen
Wei, Baoting
Chen, Xiaoqiang
Zhao, Zhe
Xiu, Yingjie
Hu, Meifang
Alahdal, Murad
Deng, Zhenhan
Wang, Daping
Liu, Jianquan
Li, Wencui
author_facet Xiao, Yu
Deng, Zhiqin
Li, Yongshen
Wei, Baoting
Chen, Xiaoqiang
Zhao, Zhe
Xiu, Yingjie
Hu, Meifang
Alahdal, Murad
Deng, Zhenhan
Wang, Daping
Liu, Jianquan
Li, Wencui
author_sort Xiao, Yu
collection PubMed
description OBJECTIVES: To screen and verify differential genes affecting the prognosis of breast cancer. METHODS: Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. RESULTS: Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). CONCLUSION: ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.
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spelling pubmed-91093162022-05-17 ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis Xiao, Yu Deng, Zhiqin Li, Yongshen Wei, Baoting Chen, Xiaoqiang Zhao, Zhe Xiu, Yingjie Hu, Meifang Alahdal, Murad Deng, Zhenhan Wang, Daping Liu, Jianquan Li, Wencui Cancer Cell Int Primary Research OBJECTIVES: To screen and verify differential genes affecting the prognosis of breast cancer. METHODS: Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. RESULTS: Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). CONCLUSION: ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer. BioMed Central 2022-05-16 /pmc/articles/PMC9109316/ /pubmed/35578283 http://dx.doi.org/10.1186/s12935-022-02611-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Primary Research
Xiao, Yu
Deng, Zhiqin
Li, Yongshen
Wei, Baoting
Chen, Xiaoqiang
Zhao, Zhe
Xiu, Yingjie
Hu, Meifang
Alahdal, Murad
Deng, Zhenhan
Wang, Daping
Liu, Jianquan
Li, Wencui
ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title_full ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title_fullStr ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title_full_unstemmed ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title_short ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
title_sort anln and ube2t are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109316/
https://www.ncbi.nlm.nih.gov/pubmed/35578283
http://dx.doi.org/10.1186/s12935-022-02611-0
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