Cargando…

The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies

BACKGROUND: Obesity is a major risk factor for atherosclerotic cardiovascular disease (ASCVD) and is associated with altered platelet function. The mean platelet volume (MPV) is a rapid measure of platelet activation and a prognostic marker in patients with cardiovascular disease. However, no meta-a...

Descripción completa

Detalles Bibliográficos
Autores principales: Nkambule, Bongani Brian, Mxinwa, Vuyolwethu, Nyambuya, Tawanda Maurice, Dludla, Phiwayinkosi Vusi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109381/
https://www.ncbi.nlm.nih.gov/pubmed/35578358
http://dx.doi.org/10.1186/s40795-022-00541-8
_version_ 1784708888132583424
author Nkambule, Bongani Brian
Mxinwa, Vuyolwethu
Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
author_facet Nkambule, Bongani Brian
Mxinwa, Vuyolwethu
Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
author_sort Nkambule, Bongani Brian
collection PubMed
description BACKGROUND: Obesity is a major risk factor for atherosclerotic cardiovascular disease (ASCVD) and is associated with altered platelet function. The mean platelet volume (MPV) is a rapid measure of platelet activation and a prognostic marker in patients with cardiovascular disease. However, no meta-analysis on the association between MPV and obesity has been conducted, and the value of monitoring the MPV in patients with obesity remains unclear. OBJECTIVE: To provide cumulative evidence on whether the mean platelet volume (MPV) is increased in individuals with obesity and to describe associations between the ASCVD-risk factors and the MPV in individuals with obesity. METHODS: This meta-analysis was prepared following the Meta-analysis Of Observational Studies (MOOSE) guidelines. We searched the PubMed and Embase database from inception until the 31st of March 2021. Studies were included when they reported the mean platelet volume in individuals with obesity and provided a suitable non-obese comparator group. The risk of bias was independently assessed by two reviewers using the Newcastle–Ottawa scale. The primary outcome of the meta-analysis was the MPV, while we considered the atherosclerotic risk profiles as a secondary outcome. RESULTS: We identified 178 citations through the PUBMED and 255 citations through EMBASE database search. In all, 13 studies met the inclusion criteria. Firstly, we report an increased mean platelet volume in individuals with obesity compared to non-obese individuals (MD 0.79; [95%CI: 0.42 to 1.16], I2 = 93.4%). Moreover, the reported increase in the MPV was inversely associated with the body mass index (Coefficient: -0.57, standard error (SE): 0.18, p < 0.001) and directly related to changes in triglyceride levels (Coefficient: 4.99, standard error (SE): 1.14, p < 0.001). CONCLUSION: This meta-analysis and meta-regression showed an increased MPV in nondiabetic individuals living with obesity. Moreover, the MPV was associated with hypertriglyceridemia, an independent predictor of atherosclerotic cardiovascular disease. Overall, the findings suggest that MPV may be a valuable rapid marker for the monitoring and risk-stratification of individuals with obesity who may be at risk of developing cardiovascular disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00541-8.
format Online
Article
Text
id pubmed-9109381
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91093812022-05-17 The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies Nkambule, Bongani Brian Mxinwa, Vuyolwethu Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi BMC Nutr Research BACKGROUND: Obesity is a major risk factor for atherosclerotic cardiovascular disease (ASCVD) and is associated with altered platelet function. The mean platelet volume (MPV) is a rapid measure of platelet activation and a prognostic marker in patients with cardiovascular disease. However, no meta-analysis on the association between MPV and obesity has been conducted, and the value of monitoring the MPV in patients with obesity remains unclear. OBJECTIVE: To provide cumulative evidence on whether the mean platelet volume (MPV) is increased in individuals with obesity and to describe associations between the ASCVD-risk factors and the MPV in individuals with obesity. METHODS: This meta-analysis was prepared following the Meta-analysis Of Observational Studies (MOOSE) guidelines. We searched the PubMed and Embase database from inception until the 31st of March 2021. Studies were included when they reported the mean platelet volume in individuals with obesity and provided a suitable non-obese comparator group. The risk of bias was independently assessed by two reviewers using the Newcastle–Ottawa scale. The primary outcome of the meta-analysis was the MPV, while we considered the atherosclerotic risk profiles as a secondary outcome. RESULTS: We identified 178 citations through the PUBMED and 255 citations through EMBASE database search. In all, 13 studies met the inclusion criteria. Firstly, we report an increased mean platelet volume in individuals with obesity compared to non-obese individuals (MD 0.79; [95%CI: 0.42 to 1.16], I2 = 93.4%). Moreover, the reported increase in the MPV was inversely associated with the body mass index (Coefficient: -0.57, standard error (SE): 0.18, p < 0.001) and directly related to changes in triglyceride levels (Coefficient: 4.99, standard error (SE): 1.14, p < 0.001). CONCLUSION: This meta-analysis and meta-regression showed an increased MPV in nondiabetic individuals living with obesity. Moreover, the MPV was associated with hypertriglyceridemia, an independent predictor of atherosclerotic cardiovascular disease. Overall, the findings suggest that MPV may be a valuable rapid marker for the monitoring and risk-stratification of individuals with obesity who may be at risk of developing cardiovascular disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-022-00541-8. BioMed Central 2022-05-16 /pmc/articles/PMC9109381/ /pubmed/35578358 http://dx.doi.org/10.1186/s40795-022-00541-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Nkambule, Bongani Brian
Mxinwa, Vuyolwethu
Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title_full The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title_fullStr The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title_full_unstemmed The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title_short The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
title_sort mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109381/
https://www.ncbi.nlm.nih.gov/pubmed/35578358
http://dx.doi.org/10.1186/s40795-022-00541-8
work_keys_str_mv AT nkambulebonganibrian themeanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT mxinwavuyolwethu themeanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT nyambuyatawandamaurice themeanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT dludlaphiwayinkosivusi themeanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT nkambulebonganibrian meanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT mxinwavuyolwethu meanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT nyambuyatawandamaurice meanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies
AT dludlaphiwayinkosivusi meanplateletvolumeandatheroscleroticcardiovascularriskfactorsinadultswithobesityasystematicreviewandmetaanalysisofobservationalstudies