Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the capability of self-renewal and functional differentiation, resulting in impairment of bone...

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Autores principales: Zhao, Yi, He, Jiawei, Qiu, Tao, Zhang, Haoyu, Liao, Li, Su, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109405/
https://www.ncbi.nlm.nih.gov/pubmed/35578312
http://dx.doi.org/10.1186/s13287-022-02852-w
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author Zhao, Yi
He, Jiawei
Qiu, Tao
Zhang, Haoyu
Liao, Li
Su, Xiaoxia
author_facet Zhao, Yi
He, Jiawei
Qiu, Tao
Zhang, Haoyu
Liao, Li
Su, Xiaoxia
author_sort Zhao, Yi
collection PubMed
description As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the capability of self-renewal and functional differentiation, resulting in impairment of bone tissue regeneration and disorder of bone tissue homeostasis. Alteration in epigenetic modification is an essential factor of BMSC dysfunction during aging. Its transferability and reversibility provide the possibility to combat BMSC aging by reversing age-related modifications. Emerging evidence demonstrates that epigenetic therapy based on aberrant epigenetic modifications could alleviate the senescence and dysfunction of stem cells. This review summarizes potential therapeutic targets for BMSC aging, introduces some potential approaches to alleviating BMSC aging, and analyzes its prospect in the clinical application of age-related bone diseases.
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spelling pubmed-91094052022-05-17 Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases Zhao, Yi He, Jiawei Qiu, Tao Zhang, Haoyu Liao, Li Su, Xiaoxia Stem Cell Res Ther Review As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the capability of self-renewal and functional differentiation, resulting in impairment of bone tissue regeneration and disorder of bone tissue homeostasis. Alteration in epigenetic modification is an essential factor of BMSC dysfunction during aging. Its transferability and reversibility provide the possibility to combat BMSC aging by reversing age-related modifications. Emerging evidence demonstrates that epigenetic therapy based on aberrant epigenetic modifications could alleviate the senescence and dysfunction of stem cells. This review summarizes potential therapeutic targets for BMSC aging, introduces some potential approaches to alleviating BMSC aging, and analyzes its prospect in the clinical application of age-related bone diseases. BioMed Central 2022-05-16 /pmc/articles/PMC9109405/ /pubmed/35578312 http://dx.doi.org/10.1186/s13287-022-02852-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhao, Yi
He, Jiawei
Qiu, Tao
Zhang, Haoyu
Liao, Li
Su, Xiaoxia
Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title_full Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title_fullStr Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title_full_unstemmed Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title_short Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
title_sort epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109405/
https://www.ncbi.nlm.nih.gov/pubmed/35578312
http://dx.doi.org/10.1186/s13287-022-02852-w
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