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Risperidone-induced neuroleptic malignant syndrome: a case report
Neuroleptic malignant syndrome (NMS) is a rare illness that results from reactions to antipsychotics. However, the diagnosis of NMS is challenging due to its atypical clinical presentation and unclear pathogenesis. We report the case of a patient with NMS induced by irregular use of antipsychotics,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109482/ https://www.ncbi.nlm.nih.gov/pubmed/35586306 http://dx.doi.org/10.1177/20451253221094960 |
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author | Deng, Ling Qiu, Zhi-Xin Wang, Mao-Yun |
author_facet | Deng, Ling Qiu, Zhi-Xin Wang, Mao-Yun |
author_sort | Deng, Ling |
collection | PubMed |
description | Neuroleptic malignant syndrome (NMS) is a rare illness that results from reactions to antipsychotics. However, the diagnosis of NMS is challenging due to its atypical clinical presentation and unclear pathogenesis. We report the case of a patient with NMS induced by irregular use of antipsychotics, especially risperidone (RSP). He had typical hyperthermia, muscle rigidity and rhabdomyolysis, which led to renal impairment. We carefully analysed the mechanism by which NMS occurred in this patient. An interesting aspect of the case is the synergistic involvement of risperidone, antidepressants, opioids and stress. Because of these complex predisposing factors, it is difficult to completely rule out the diagnosis of malignant hyperthermia (MH). In addition, the rare phenomenon of elevated lipase and amylase was observed in this patient. |
format | Online Article Text |
id | pubmed-9109482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91094822022-05-17 Risperidone-induced neuroleptic malignant syndrome: a case report Deng, Ling Qiu, Zhi-Xin Wang, Mao-Yun Ther Adv Psychopharmacol Case Report Neuroleptic malignant syndrome (NMS) is a rare illness that results from reactions to antipsychotics. However, the diagnosis of NMS is challenging due to its atypical clinical presentation and unclear pathogenesis. We report the case of a patient with NMS induced by irregular use of antipsychotics, especially risperidone (RSP). He had typical hyperthermia, muscle rigidity and rhabdomyolysis, which led to renal impairment. We carefully analysed the mechanism by which NMS occurred in this patient. An interesting aspect of the case is the synergistic involvement of risperidone, antidepressants, opioids and stress. Because of these complex predisposing factors, it is difficult to completely rule out the diagnosis of malignant hyperthermia (MH). In addition, the rare phenomenon of elevated lipase and amylase was observed in this patient. SAGE Publications 2022-05-14 /pmc/articles/PMC9109482/ /pubmed/35586306 http://dx.doi.org/10.1177/20451253221094960 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Deng, Ling Qiu, Zhi-Xin Wang, Mao-Yun Risperidone-induced neuroleptic malignant syndrome: a case report |
title | Risperidone-induced neuroleptic malignant syndrome: a case
report |
title_full | Risperidone-induced neuroleptic malignant syndrome: a case
report |
title_fullStr | Risperidone-induced neuroleptic malignant syndrome: a case
report |
title_full_unstemmed | Risperidone-induced neuroleptic malignant syndrome: a case
report |
title_short | Risperidone-induced neuroleptic malignant syndrome: a case
report |
title_sort | risperidone-induced neuroleptic malignant syndrome: a case
report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109482/ https://www.ncbi.nlm.nih.gov/pubmed/35586306 http://dx.doi.org/10.1177/20451253221094960 |
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