Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis

Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in Mycobacterium tuberculosis (Mtb) infection. Here, we in...

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Detalles Bibliográficos
Autores principales: Bomfim, Caio C. B., Fisher, Logan, Amaral, Eduardo P., Mittereder, Lara, McCann, Katelyn, Correa, André A. S., Namasivayam, Sivaranjani, Swamydas, Muthulekha, Moayeri, Mahtab, Weiss, Jonathan M., Chari, Raj, McVicar, Daniel W., Costa, Diego L., D’Império Lima, Maria R., Sher, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109611/
https://www.ncbi.nlm.nih.gov/pubmed/35586249
http://dx.doi.org/10.3389/fcimb.2022.862582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109611/
https://www.ncbi.nlm.nih.gov/pubmed/35586249
http://dx.doi.org/10.3389/fcimb.2022.862582

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