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Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats
Introduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pleiades Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109666/ https://www.ncbi.nlm.nih.gov/pubmed/35599639 http://dx.doi.org/10.1134/S0022093022020119 |
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author | Lektemur Alpan, A. Torumtay Cin, G. Özmen, Ö. Doğan, M. F. Şahin, Y. |
author_facet | Lektemur Alpan, A. Torumtay Cin, G. Özmen, Ö. Doğan, M. F. Şahin, Y. |
author_sort | Lektemur Alpan, A. |
collection | PubMed |
description | Introduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone metabolism. Experimental: Fifty healthy adult male Sprague-Dawley rats (2–3 months old) were randomly divided into five equal groups (n = 10): Control, Favi 20, Favi 100, Favi 20+Vit C, Favi 100+Vit C. Favipiravir (20 mg/kg and 100 mg/kg, i.m.) and Vit C (150 mg/kg/day, oral) were administered to the rats for 14 days. Alveolar bone loss (ABL) and histopathological changes were examined using a light microscope. Immunohistochemistry was used to determine levels of receptor activator of nuclear factor kappa-B ligand (RANKL), caspase-3, bone morphogenic protein 2 (BMP-2) and alkaline phosphatase (ALP) in the bone tissues. Results: Favipiravir increased the levels of RANKL and caspase-3 expression but decreased BMP-2 and ALP levels in a dose-dependent manner. Favi 20+Vit C and Favi 100 +Vit C groups showed decreased RANKL and caspase-3 levels in addition to increased BMP-2 and ALP levels. Conclusion: Favipiravir can cause histopathological damage to the periodontium, but administration of favipiravir combined with Vit C can provide a protective effect against this damage. |
format | Online Article Text |
id | pubmed-9109666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-91096662022-05-16 Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats Lektemur Alpan, A. Torumtay Cin, G. Özmen, Ö. Doğan, M. F. Şahin, Y. J Evol Biochem Physiol Experimental Papers Introduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone metabolism. Experimental: Fifty healthy adult male Sprague-Dawley rats (2–3 months old) were randomly divided into five equal groups (n = 10): Control, Favi 20, Favi 100, Favi 20+Vit C, Favi 100+Vit C. Favipiravir (20 mg/kg and 100 mg/kg, i.m.) and Vit C (150 mg/kg/day, oral) were administered to the rats for 14 days. Alveolar bone loss (ABL) and histopathological changes were examined using a light microscope. Immunohistochemistry was used to determine levels of receptor activator of nuclear factor kappa-B ligand (RANKL), caspase-3, bone morphogenic protein 2 (BMP-2) and alkaline phosphatase (ALP) in the bone tissues. Results: Favipiravir increased the levels of RANKL and caspase-3 expression but decreased BMP-2 and ALP levels in a dose-dependent manner. Favi 20+Vit C and Favi 100 +Vit C groups showed decreased RANKL and caspase-3 levels in addition to increased BMP-2 and ALP levels. Conclusion: Favipiravir can cause histopathological damage to the periodontium, but administration of favipiravir combined with Vit C can provide a protective effect against this damage. Pleiades Publishing 2022-05-16 2022 /pmc/articles/PMC9109666/ /pubmed/35599639 http://dx.doi.org/10.1134/S0022093022020119 Text en © Pleiades Publishing, Ltd. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Experimental Papers Lektemur Alpan, A. Torumtay Cin, G. Özmen, Ö. Doğan, M. F. Şahin, Y. Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title_full | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title_fullStr | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title_full_unstemmed | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title_short | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats |
title_sort | evaluation of the effects of favipiravir combined with vitamin c on alveolar bone in rats |
topic | Experimental Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109666/ https://www.ncbi.nlm.nih.gov/pubmed/35599639 http://dx.doi.org/10.1134/S0022093022020119 |
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