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High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers
The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of different synthetic parameters leading to the production of UiO-66 crystals smalle...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109712/ https://www.ncbi.nlm.nih.gov/pubmed/35467684 http://dx.doi.org/10.1039/d1nr08305h |
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author | Ceballos, Manuel Cedrún-Morales, Manuela Rodríguez-Pérez, Manuel Funes-Hernando, Samuel Vila-Fungueiriño, José Manuel Zampini, Giulia Navarro Poupard, Maria F. Polo, Ester del Pino, Pablo Pelaz, Beatriz |
author_facet | Ceballos, Manuel Cedrún-Morales, Manuela Rodríguez-Pérez, Manuel Funes-Hernando, Samuel Vila-Fungueiriño, José Manuel Zampini, Giulia Navarro Poupard, Maria F. Polo, Ester del Pino, Pablo Pelaz, Beatriz |
author_sort | Ceballos, Manuel |
collection | PubMed |
description | The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of different synthetic parameters leading to the production of UiO-66 crystals smaller than 100 nm. Of note, we demonstrate the co-modulator role conferred by halide ions, not only to produce NMOFs with precise morphology and size, but also to significantly improve the reaction yield. The resulting NMOFs are highly crystalline and exhibit sustained colloidal stability in different biologically relevant media. As a proof of concept, these NMOFs were loaded with Rhodamine 6G (R6G), which remained trapped in most common biologically relevant media. When incubated with living mammalian cells, the R6G-loaded NMOFs were efficiently internalized and did not impair cell viability even at relatively high doses. |
format | Online Article Text |
id | pubmed-9109712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-91097122022-06-13 High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers Ceballos, Manuel Cedrún-Morales, Manuela Rodríguez-Pérez, Manuel Funes-Hernando, Samuel Vila-Fungueiriño, José Manuel Zampini, Giulia Navarro Poupard, Maria F. Polo, Ester del Pino, Pablo Pelaz, Beatriz Nanoscale Chemistry The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of different synthetic parameters leading to the production of UiO-66 crystals smaller than 100 nm. Of note, we demonstrate the co-modulator role conferred by halide ions, not only to produce NMOFs with precise morphology and size, but also to significantly improve the reaction yield. The resulting NMOFs are highly crystalline and exhibit sustained colloidal stability in different biologically relevant media. As a proof of concept, these NMOFs were loaded with Rhodamine 6G (R6G), which remained trapped in most common biologically relevant media. When incubated with living mammalian cells, the R6G-loaded NMOFs were efficiently internalized and did not impair cell viability even at relatively high doses. The Royal Society of Chemistry 2022-04-25 /pmc/articles/PMC9109712/ /pubmed/35467684 http://dx.doi.org/10.1039/d1nr08305h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Ceballos, Manuel Cedrún-Morales, Manuela Rodríguez-Pérez, Manuel Funes-Hernando, Samuel Vila-Fungueiriño, José Manuel Zampini, Giulia Navarro Poupard, Maria F. Polo, Ester del Pino, Pablo Pelaz, Beatriz High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title | High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title_full | High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title_fullStr | High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title_full_unstemmed | High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title_short | High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers |
title_sort | high-yield halide-assisted synthesis of metal–organic framework uio-based nanocarriers |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109712/ https://www.ncbi.nlm.nih.gov/pubmed/35467684 http://dx.doi.org/10.1039/d1nr08305h |
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