Coordinated motion of molecular motors on DNA chains with branch topology

To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK(C) on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK(C) motors...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Di, Chen, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109741/
https://www.ncbi.nlm.nih.gov/pubmed/35601132
http://dx.doi.org/10.1007/s10409-021-09045-x
Descripción
Sumario:To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK(C) on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK(C) motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsK(C) motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsK(C) motors. We further suggest the potential application of motors of FtsK(C), together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.

Ejemplares similares