Coordinated motion of molecular motors on DNA chains with branch topology

To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK(C) on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK(C) motors...

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Detalles Bibliográficos
Autores principales: Lu, Di, Chen, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109741/
https://www.ncbi.nlm.nih.gov/pubmed/35601132
http://dx.doi.org/10.1007/s10409-021-09045-x
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author Lu, Di
Chen, Bin
author_facet Lu, Di
Chen, Bin
author_sort Lu, Di
collection PubMed
description To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK(C) on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK(C) motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsK(C) motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsK(C) motors. We further suggest the potential application of motors of FtsK(C), together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.
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spelling pubmed-91097412022-05-17 Coordinated motion of molecular motors on DNA chains with branch topology Lu, Di Chen, Bin Acta Mech Sin Research Paper To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK(C) on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK(C) motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsK(C) motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsK(C) motors. We further suggest the potential application of motors of FtsK(C), together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels. The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences 2022-02-16 2022 /pmc/articles/PMC9109741/ /pubmed/35601132 http://dx.doi.org/10.1007/s10409-021-09045-x Text en © The Chinese Society of Theoretical and Applied Mechanics and Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Paper
Lu, Di
Chen, Bin
Coordinated motion of molecular motors on DNA chains with branch topology
title Coordinated motion of molecular motors on DNA chains with branch topology
title_full Coordinated motion of molecular motors on DNA chains with branch topology
title_fullStr Coordinated motion of molecular motors on DNA chains with branch topology
title_full_unstemmed Coordinated motion of molecular motors on DNA chains with branch topology
title_short Coordinated motion of molecular motors on DNA chains with branch topology
title_sort coordinated motion of molecular motors on dna chains with branch topology
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109741/
https://www.ncbi.nlm.nih.gov/pubmed/35601132
http://dx.doi.org/10.1007/s10409-021-09045-x
work_keys_str_mv AT ludi coordinatedmotionofmolecularmotorsondnachainswithbranchtopology
AT chenbin coordinatedmotionofmolecularmotorsondnachainswithbranchtopology

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