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Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors

Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to th...

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Autores principales: Tune, Bernadette Xin Jie, Sim, Maw Shin, Poh, Chit Laa, Guad, Rhanye Mac, Woon, Choy Ker, Hazarika, Iswar, Das, Anju, Gopinath, Subash C. B., Rajan, Mariappan, Sekar, Mahendran, Subramaniyan, Vetriselvan, Fuloria, Neeraj Kumar, Fuloria, Shivkanya, Batumalaie, Kalaivani, Wu, Yuan Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110224/
https://www.ncbi.nlm.nih.gov/pubmed/35586209
http://dx.doi.org/10.1155/2022/3249766
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author Tune, Bernadette Xin Jie
Sim, Maw Shin
Poh, Chit Laa
Guad, Rhanye Mac
Woon, Choy Ker
Hazarika, Iswar
Das, Anju
Gopinath, Subash C. B.
Rajan, Mariappan
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Batumalaie, Kalaivani
Wu, Yuan Seng
author_facet Tune, Bernadette Xin Jie
Sim, Maw Shin
Poh, Chit Laa
Guad, Rhanye Mac
Woon, Choy Ker
Hazarika, Iswar
Das, Anju
Gopinath, Subash C. B.
Rajan, Mariappan
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Batumalaie, Kalaivani
Wu, Yuan Seng
author_sort Tune, Bernadette Xin Jie
collection PubMed
description Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (MMPs), a class of zinc and calcium-chelated enzymes, are found to be key players in driving cancer migration and metastasis through EMT induction. The aim of this review is to discuss the regulatory roles and associated molecular mechanisms of specific MMPs in regulating chemoresistance, particularly EMT initiation and resistance to apoptosis. A brief presentation on their potential diagnostic and prognostic values was also deciphered. It also aimed to describe existing MMP inhibitors and the potential of utilizing other strategies to inhibit MMPs to reduce chemoresistance, such as upstream inhibition of MMP expressions and MMP-responsive nanomaterials to deliver drugs as well as epigenetic regulations. Hence, manipulation of MMP expression can be a powerful tool to aid in treating patients with chemo-resistant cancers. However, much still needs to be done to bring the solution from bench to bedside.
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spelling pubmed-91102242022-05-17 Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors Tune, Bernadette Xin Jie Sim, Maw Shin Poh, Chit Laa Guad, Rhanye Mac Woon, Choy Ker Hazarika, Iswar Das, Anju Gopinath, Subash C. B. Rajan, Mariappan Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Batumalaie, Kalaivani Wu, Yuan Seng J Oncol Review Article Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (MMPs), a class of zinc and calcium-chelated enzymes, are found to be key players in driving cancer migration and metastasis through EMT induction. The aim of this review is to discuss the regulatory roles and associated molecular mechanisms of specific MMPs in regulating chemoresistance, particularly EMT initiation and resistance to apoptosis. A brief presentation on their potential diagnostic and prognostic values was also deciphered. It also aimed to describe existing MMP inhibitors and the potential of utilizing other strategies to inhibit MMPs to reduce chemoresistance, such as upstream inhibition of MMP expressions and MMP-responsive nanomaterials to deliver drugs as well as epigenetic regulations. Hence, manipulation of MMP expression can be a powerful tool to aid in treating patients with chemo-resistant cancers. However, much still needs to be done to bring the solution from bench to bedside. Hindawi 2022-05-09 /pmc/articles/PMC9110224/ /pubmed/35586209 http://dx.doi.org/10.1155/2022/3249766 Text en Copyright © 2022 Bernadette Xin Jie Tune et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tune, Bernadette Xin Jie
Sim, Maw Shin
Poh, Chit Laa
Guad, Rhanye Mac
Woon, Choy Ker
Hazarika, Iswar
Das, Anju
Gopinath, Subash C. B.
Rajan, Mariappan
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Batumalaie, Kalaivani
Wu, Yuan Seng
Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title_full Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title_fullStr Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title_full_unstemmed Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title_short Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
title_sort matrix metalloproteinases in chemoresistance: regulatory roles, molecular interactions, and potential inhibitors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110224/
https://www.ncbi.nlm.nih.gov/pubmed/35586209
http://dx.doi.org/10.1155/2022/3249766
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