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Sensitive identification of neoantigens and cognate TCRs in human solid tumors
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-i...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110298/ https://www.ncbi.nlm.nih.gov/pubmed/34782741 http://dx.doi.org/10.1038/s41587-021-01072-6 |
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| author | Arnaud, Marion Chiffelle, Johanna Genolet, Raphael Navarro Rodrigo, Blanca Perez, Marta A. S. Huber, Florian Magnin, Morgane Nguyen-Ngoc, Tu Guillaume, Philippe Baumgaertner, Petra Chong, Chloe Stevenson, Brian J. Gfeller, David Irving, Melita Speiser, Daniel E. Schmidt, Julien Zoete, Vincent Kandalaft, Lana E. Bassani-Sternberg, Michal Bobisse, Sara Coukos, George Harari, Alexandre |
| author_facet | Arnaud, Marion Chiffelle, Johanna Genolet, Raphael Navarro Rodrigo, Blanca Perez, Marta A. S. Huber, Florian Magnin, Morgane Nguyen-Ngoc, Tu Guillaume, Philippe Baumgaertner, Petra Chong, Chloe Stevenson, Brian J. Gfeller, David Irving, Melita Speiser, Daniel E. Schmidt, Julien Zoete, Vincent Kandalaft, Lana E. Bassani-Sternberg, Michal Bobisse, Sara Coukos, George Harari, Alexandre |
| author_sort | Arnaud, Marion |
| collection | PubMed |
| description | The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice. |
| format | Online Article Text |
| id | pubmed-9110298 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91102982022-05-18 Sensitive identification of neoantigens and cognate TCRs in human solid tumors Arnaud, Marion Chiffelle, Johanna Genolet, Raphael Navarro Rodrigo, Blanca Perez, Marta A. S. Huber, Florian Magnin, Morgane Nguyen-Ngoc, Tu Guillaume, Philippe Baumgaertner, Petra Chong, Chloe Stevenson, Brian J. Gfeller, David Irving, Melita Speiser, Daniel E. Schmidt, Julien Zoete, Vincent Kandalaft, Lana E. Bassani-Sternberg, Michal Bobisse, Sara Coukos, George Harari, Alexandre Nat Biotechnol Brief Communication The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice. Nature Publishing Group US 2021-11-15 2022 /pmc/articles/PMC9110298/ /pubmed/34782741 http://dx.doi.org/10.1038/s41587-021-01072-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Arnaud, Marion Chiffelle, Johanna Genolet, Raphael Navarro Rodrigo, Blanca Perez, Marta A. S. Huber, Florian Magnin, Morgane Nguyen-Ngoc, Tu Guillaume, Philippe Baumgaertner, Petra Chong, Chloe Stevenson, Brian J. Gfeller, David Irving, Melita Speiser, Daniel E. Schmidt, Julien Zoete, Vincent Kandalaft, Lana E. Bassani-Sternberg, Michal Bobisse, Sara Coukos, George Harari, Alexandre Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title | Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title_full | Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title_fullStr | Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title_full_unstemmed | Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title_short | Sensitive identification of neoantigens and cognate TCRs in human solid tumors |
| title_sort | sensitive identification of neoantigens and cognate tcrs in human solid tumors |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110298/ https://www.ncbi.nlm.nih.gov/pubmed/34782741 http://dx.doi.org/10.1038/s41587-021-01072-6 |
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