Sensitive identification of neoantigens and cognate TCRs in human solid tumors

The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-i...

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Detalles Bibliográficos
Autores principales: Arnaud, Marion, Chiffelle, Johanna, Genolet, Raphael, Navarro Rodrigo, Blanca, Perez, Marta A. S., Huber, Florian, Magnin, Morgane, Nguyen-Ngoc, Tu, Guillaume, Philippe, Baumgaertner, Petra, Chong, Chloe, Stevenson, Brian J., Gfeller, David, Irving, Melita, Speiser, Daniel E., Schmidt, Julien, Zoete, Vincent, Kandalaft, Lana E., Bassani-Sternberg, Michal, Bobisse, Sara, Coukos, George, Harari, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110298/
https://www.ncbi.nlm.nih.gov/pubmed/34782741
http://dx.doi.org/10.1038/s41587-021-01072-6

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