Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indir...

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Detalles Bibliográficos
Autores principales: Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared V., Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret I., Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njølstad, Pål Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hägg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Øyvind, Willer, Cristen J., Åsvold, Bjørn Olav, Koellinger, Philipp D., Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Benjamin, Daniel J., Turley, Patrick, Evans, David M., Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110300/
https://www.ncbi.nlm.nih.gov/pubmed/35534559
http://dx.doi.org/10.1038/s41588-022-01062-7

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