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COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes

AIM: There is a high demand for information on COVID-19 vaccination for patients with childhood epilepsy with centrotemporal spikes (BECTS). Patients with this condition need a stable, daily life; unfortunately, the decision of vaccination is not easy for their parents. We evaluated patients with BE...

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Detalles Bibliográficos
Autores principales: Yang, Xinyu, Wu, Lulu, Zheng, Dandan, Yang, Bin, Wu, De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110311/
https://www.ncbi.nlm.nih.gov/pubmed/35952506
http://dx.doi.org/10.1016/j.yebeh.2022.108744
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author Yang, Xinyu
Wu, Lulu
Zheng, Dandan
Yang, Bin
Wu, De
author_facet Yang, Xinyu
Wu, Lulu
Zheng, Dandan
Yang, Bin
Wu, De
author_sort Yang, Xinyu
collection PubMed
description AIM: There is a high demand for information on COVID-19 vaccination for patients with childhood epilepsy with centrotemporal spikes (BECTS). Patients with this condition need a stable, daily life; unfortunately, the decision of vaccination is not easy for their parents. We evaluated patients with BECTS for symptoms and seizure control after COVID-19 vaccination. METHODS: We asked the caregivers of all patients who visited our hospital to report their vaccination status, and if vaccinated, their experience in terms of adverse effects and seizure control after the second dose of the four Chinese-approved COVID-19 vaccines. RESULTS: Seventy-seven children had received their second COVID-19 vaccine dose: 58 of 77 (75.3%) received Sinopharm (Beijing): BBIBP-CorV (Vero cells) and 16 (20.8%) received CanSino: Ad5-nCoV. Twenty of seventy-seven (25.97%) patients with BECTS reported having side effects; all effects were mild that could be relieved themselves. For Sinopharm (Beijing): BBIBP-CorV (Vero cells), the most frequent local side effect reported by the parents was pain at the site of injection (17.24%) and systematic side effect was fatigue (15.52%). For CanSino: Ad5-nCoV, the most reported local side effect was pain at the site of injection (6.25%). All parents reported that their child’s side effects could be relieved by themselves. No patient reported status epilepticus or exacerbation of a pre-existing condition. If non-vaccinated, the cause of hesitation was explored: 40% of parents worried about inducing seizures, 19% of parents worried about vaccine side effects, 32% of parents worried about the vaccine-antiepileptic drug interactions, and 9% of parents feared for their child’s physical condition. More than 34.1% of parents accepted that the decision to get the vaccine for their child was difficult. Over 90% of parents believe that research on the safety and tolerability of vaccination would help them to make the decision. CONCLUSION: Our data suggest that COVID-19 vaccination is well tolerated and safe in patients below 18 years of age having BECTS, thereby supporting the recommendation of vaccination.
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spelling pubmed-91103112022-05-17 COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes Yang, Xinyu Wu, Lulu Zheng, Dandan Yang, Bin Wu, De Epilepsy Behav Article AIM: There is a high demand for information on COVID-19 vaccination for patients with childhood epilepsy with centrotemporal spikes (BECTS). Patients with this condition need a stable, daily life; unfortunately, the decision of vaccination is not easy for their parents. We evaluated patients with BECTS for symptoms and seizure control after COVID-19 vaccination. METHODS: We asked the caregivers of all patients who visited our hospital to report their vaccination status, and if vaccinated, their experience in terms of adverse effects and seizure control after the second dose of the four Chinese-approved COVID-19 vaccines. RESULTS: Seventy-seven children had received their second COVID-19 vaccine dose: 58 of 77 (75.3%) received Sinopharm (Beijing): BBIBP-CorV (Vero cells) and 16 (20.8%) received CanSino: Ad5-nCoV. Twenty of seventy-seven (25.97%) patients with BECTS reported having side effects; all effects were mild that could be relieved themselves. For Sinopharm (Beijing): BBIBP-CorV (Vero cells), the most frequent local side effect reported by the parents was pain at the site of injection (17.24%) and systematic side effect was fatigue (15.52%). For CanSino: Ad5-nCoV, the most reported local side effect was pain at the site of injection (6.25%). All parents reported that their child’s side effects could be relieved by themselves. No patient reported status epilepticus or exacerbation of a pre-existing condition. If non-vaccinated, the cause of hesitation was explored: 40% of parents worried about inducing seizures, 19% of parents worried about vaccine side effects, 32% of parents worried about the vaccine-antiepileptic drug interactions, and 9% of parents feared for their child’s physical condition. More than 34.1% of parents accepted that the decision to get the vaccine for their child was difficult. Over 90% of parents believe that research on the safety and tolerability of vaccination would help them to make the decision. CONCLUSION: Our data suggest that COVID-19 vaccination is well tolerated and safe in patients below 18 years of age having BECTS, thereby supporting the recommendation of vaccination. Elsevier Inc. 2022-09 2022-05-17 /pmc/articles/PMC9110311/ /pubmed/35952506 http://dx.doi.org/10.1016/j.yebeh.2022.108744 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yang, Xinyu
Wu, Lulu
Zheng, Dandan
Yang, Bin
Wu, De
COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title_full COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title_fullStr COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title_full_unstemmed COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title_short COVID-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
title_sort covid-19 vaccination for patients with benign childhood epilepsy with centrotemporal spikes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110311/
https://www.ncbi.nlm.nih.gov/pubmed/35952506
http://dx.doi.org/10.1016/j.yebeh.2022.108744
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