Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19

Disease recovery dynamics are often difficult to assess, as patients display heterogeneous recovery courses. To model recovery dynamics, exemplified by severe COVID-19, we apply a computational scheme on longitudinally sampled blood transcriptomes, generating recovery states, which we then link to c...

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Detalles Bibliográficos
Autores principales: Frishberg, Amit, Kooistra, Emma, Nuesch-Germano, Melanie, Pecht, Tal, Milman, Neta, Reusch, Nico, Warnat-Herresthal, Stefanie, Bruse, Niklas, Händler, Kristian, Theis, Heidi, Kraut, Michael, van Rijssen, Esther, van Cranenbroek, Bram, Koenen, Hans JPM., Heesakkers, Hidde, van den Boogaard, Mark, Zegers, Marieke, Pickkers, Peter, Becker, Matthias, Aschenbrenner, Anna C., Ulas, Thomas, Theis, Fabian J., Shen-Orr, Shai S., Schultze, Joachim L., Kox, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110324/
https://www.ncbi.nlm.nih.gov/pubmed/35675822
http://dx.doi.org/10.1016/j.xcrm.2022.100652

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