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Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation

Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent (18)FDG PET prior to CI surgery. Average normalized...

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Autores principales: Speck, Iva, Arndt, Susan, Thurow, Johannes, Rau, Alexander, Aschendorff, Antje, Meyer, Philipp T., Frings, Lars, Blazhenets, Ganna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110403/
https://www.ncbi.nlm.nih.gov/pubmed/35577877
http://dx.doi.org/10.1038/s41598-022-12139-y
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author Speck, Iva
Arndt, Susan
Thurow, Johannes
Rau, Alexander
Aschendorff, Antje
Meyer, Philipp T.
Frings, Lars
Blazhenets, Ganna
author_facet Speck, Iva
Arndt, Susan
Thurow, Johannes
Rau, Alexander
Aschendorff, Antje
Meyer, Philipp T.
Frings, Lars
Blazhenets, Ganna
author_sort Speck, Iva
collection PubMed
description Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent (18)FDG PET prior to CI surgery. Average normalized (18)FDG uptake of 25% of voxels with highest uptake was calculated for the PAC employing a probabilistic atlas and cerebellar cortex as reference. Differences in glucose metabolism of the PAC were assessed by an asymmetry index (AI-PAC). We tested the correlation between outcome of CI surgery (6 months post implantation), AI-PAC and clinical predictors. Pre-operative AI-PAC showed a positive correlation with speech recognition with CI (significant for sentences and numbers; trend for monosyllabic words). With a pre-operative AI-PAC ≥ 4.2%, patients reached good CI outcome in sentence recognition of 59–90% and number recognition of 90–100% and less favorable CI outcome in monosyllabic word recognition of 25–45%. Age at symptom onset was significantly associated with all measures of speech recognition, while deafness duration was only associated with sentence recognition. AI-PAC allows for a reliable and quantitative pre-operative prediction of early improvement in speech recognition after CI. (18)FDG PET may be a valuable addition to the objective pre-operative assessment of CI candidates. Further studies in larger cohorts and with longer follow-up times are needed.
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spelling pubmed-91104032022-05-18 Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation Speck, Iva Arndt, Susan Thurow, Johannes Rau, Alexander Aschendorff, Antje Meyer, Philipp T. Frings, Lars Blazhenets, Ganna Sci Rep Article Patients with asymmetric hearing loss show an asymmetry of glucose metabolism of the primary auditory cortex (PAC). We investigated whether this asymmetry could serve as an objective predictor for speech recognition with CI. Nine patients underwent (18)FDG PET prior to CI surgery. Average normalized (18)FDG uptake of 25% of voxels with highest uptake was calculated for the PAC employing a probabilistic atlas and cerebellar cortex as reference. Differences in glucose metabolism of the PAC were assessed by an asymmetry index (AI-PAC). We tested the correlation between outcome of CI surgery (6 months post implantation), AI-PAC and clinical predictors. Pre-operative AI-PAC showed a positive correlation with speech recognition with CI (significant for sentences and numbers; trend for monosyllabic words). With a pre-operative AI-PAC ≥ 4.2%, patients reached good CI outcome in sentence recognition of 59–90% and number recognition of 90–100% and less favorable CI outcome in monosyllabic word recognition of 25–45%. Age at symptom onset was significantly associated with all measures of speech recognition, while deafness duration was only associated with sentence recognition. AI-PAC allows for a reliable and quantitative pre-operative prediction of early improvement in speech recognition after CI. (18)FDG PET may be a valuable addition to the objective pre-operative assessment of CI candidates. Further studies in larger cohorts and with longer follow-up times are needed. Nature Publishing Group UK 2022-05-16 /pmc/articles/PMC9110403/ /pubmed/35577877 http://dx.doi.org/10.1038/s41598-022-12139-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Speck, Iva
Arndt, Susan
Thurow, Johannes
Rau, Alexander
Aschendorff, Antje
Meyer, Philipp T.
Frings, Lars
Blazhenets, Ganna
Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title_full Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title_fullStr Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title_full_unstemmed Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title_short Neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
title_sort neural activity of the auditory cortex predicts speech recognition of patients with asymmetric hearing loss after cochlear implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110403/
https://www.ncbi.nlm.nih.gov/pubmed/35577877
http://dx.doi.org/10.1038/s41598-022-12139-y
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