Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

Soluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3β or...

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Detalles Bibliográficos
Autores principales: Meng, Jonathan X., Zhang, Yu, Saman, Dominik, Haider, Arshad M., De, Suman, Sang, Jason C., Brown, Karen, Jiang, Kun, Humphrey, Jane, Julian, Linda, Hidari, Eric, Lee, Steven F., Balmus, Gabriel, Floto, R. Andres, Bryant, Clare E., Benesch, Justin L. P., Ye, Yu, Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110413/
https://www.ncbi.nlm.nih.gov/pubmed/35577786
http://dx.doi.org/10.1038/s41467-022-30461-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110413/
https://www.ncbi.nlm.nih.gov/pubmed/35577786
http://dx.doi.org/10.1038/s41467-022-30461-x

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