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Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study

Asthmatic patients are generally considered to have an increased risk of mortality compared with subjects without asthma. However, this issue has been less evaluated using nationally representative data. Moreover, it is unclear whether respiratory comorbidities other than chronic obstructive pulmona...

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Autores principales: Yeo, Yoomi, Lee, Hyun, Ryu, Jiin, Chung, Sung Jun, Park, Tai Sun, Park, Dong Won, Kim, Sang-Heon, Kim, Tae Hyung, Sohn, Jang Won, Yoon, Ho Joo, Min, Kyung Hoon, Moon, Ji-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110422/
https://www.ncbi.nlm.nih.gov/pubmed/35577832
http://dx.doi.org/10.1038/s41598-022-12103-w
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author Yeo, Yoomi
Lee, Hyun
Ryu, Jiin
Chung, Sung Jun
Park, Tai Sun
Park, Dong Won
Kim, Sang-Heon
Kim, Tae Hyung
Sohn, Jang Won
Yoon, Ho Joo
Min, Kyung Hoon
Moon, Ji-Yong
author_facet Yeo, Yoomi
Lee, Hyun
Ryu, Jiin
Chung, Sung Jun
Park, Tai Sun
Park, Dong Won
Kim, Sang-Heon
Kim, Tae Hyung
Sohn, Jang Won
Yoon, Ho Joo
Min, Kyung Hoon
Moon, Ji-Yong
author_sort Yeo, Yoomi
collection PubMed
description Asthmatic patients are generally considered to have an increased risk of mortality compared with subjects without asthma. However, this issue has been less evaluated using nationally representative data. Moreover, it is unclear whether respiratory comorbidities other than chronic obstructive pulmonary disease (COPD) are associated with increased mortality in asthmatic patients compared with subjects without. Using a nationally representative sample database, we performed a retrospective cohort study of patients with asthma and age-sex-matched control cohort. We estimated the hazard ratio (HR) and stratified the asthma cohort based on respiratory comorbidities. During a median 8.9-year follow-up, the overall mortality rate was higher in the asthma cohort than in the control cohort (p < 0.001). The hazard ratio (HR) for overall mortality in the asthma cohort compared with the control cohort was 1.13. The effects of asthma on overall mortality were more evident in males, patients under medical aid, and subjects with COPD. Respiratory comorbidities were significantly associated with increased risk of overall mortality in asthmatic patients compared with controls (adjusted HRs; 1.48 for COPD, 1.40 for bronchiectasis, 4.08 for lung cancer, and 1.59 for pneumonia). While asthma and lung cancer showed an additive effect only on overall mortality, asthma and other respiratory comorbidities (COPD, pneumonia, and bronchiectasis) had additive effects only on respiratory mortality. Patients with asthma had a higher overall mortality rate compared with subjects without asthma. Respiratory comorbidities showed an additive effect on overall or respiratory mortality in patients with asthma.
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spelling pubmed-91104222022-05-18 Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study Yeo, Yoomi Lee, Hyun Ryu, Jiin Chung, Sung Jun Park, Tai Sun Park, Dong Won Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Yoon, Ho Joo Min, Kyung Hoon Moon, Ji-Yong Sci Rep Article Asthmatic patients are generally considered to have an increased risk of mortality compared with subjects without asthma. However, this issue has been less evaluated using nationally representative data. Moreover, it is unclear whether respiratory comorbidities other than chronic obstructive pulmonary disease (COPD) are associated with increased mortality in asthmatic patients compared with subjects without. Using a nationally representative sample database, we performed a retrospective cohort study of patients with asthma and age-sex-matched control cohort. We estimated the hazard ratio (HR) and stratified the asthma cohort based on respiratory comorbidities. During a median 8.9-year follow-up, the overall mortality rate was higher in the asthma cohort than in the control cohort (p < 0.001). The hazard ratio (HR) for overall mortality in the asthma cohort compared with the control cohort was 1.13. The effects of asthma on overall mortality were more evident in males, patients under medical aid, and subjects with COPD. Respiratory comorbidities were significantly associated with increased risk of overall mortality in asthmatic patients compared with controls (adjusted HRs; 1.48 for COPD, 1.40 for bronchiectasis, 4.08 for lung cancer, and 1.59 for pneumonia). While asthma and lung cancer showed an additive effect only on overall mortality, asthma and other respiratory comorbidities (COPD, pneumonia, and bronchiectasis) had additive effects only on respiratory mortality. Patients with asthma had a higher overall mortality rate compared with subjects without asthma. Respiratory comorbidities showed an additive effect on overall or respiratory mortality in patients with asthma. Nature Publishing Group UK 2022-05-16 /pmc/articles/PMC9110422/ /pubmed/35577832 http://dx.doi.org/10.1038/s41598-022-12103-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yeo, Yoomi
Lee, Hyun
Ryu, Jiin
Chung, Sung Jun
Park, Tai Sun
Park, Dong Won
Kim, Sang-Heon
Kim, Tae Hyung
Sohn, Jang Won
Yoon, Ho Joo
Min, Kyung Hoon
Moon, Ji-Yong
Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title_full Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title_fullStr Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title_full_unstemmed Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title_short Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
title_sort additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110422/
https://www.ncbi.nlm.nih.gov/pubmed/35577832
http://dx.doi.org/10.1038/s41598-022-12103-w
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