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Drug repositioning of polaprezinc for bone fracture healing
Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110432/ https://www.ncbi.nlm.nih.gov/pubmed/35577977 http://dx.doi.org/10.1038/s42003-022-03424-7 |
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author | Ko, Eun Ae Park, Yoo Jung Yoon, Dong Suk Lee, Kyoung-Mi Kim, Jihyun Jung, Sujin Lee, Jin Woo Park, Kwang Hwan |
author_facet | Ko, Eun Ae Park, Yoo Jung Yoon, Dong Suk Lee, Kyoung-Mi Kim, Jihyun Jung, Sujin Lee, Jin Woo Park, Kwang Hwan |
author_sort | Ko, Eun Ae |
collection | PubMed |
description | Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential of mouse bone marrow-derived monocytes. In mouse experimental models with bone fractures, oral administration of polaprezinc accelerated fracture healing and maintained a high number of both osteoblasts and osteoclasts in the fracture areas. Collectively, polaprezinc promotes the fracture healing process efficiently by enhancing the activity of both osteoblasts and osteoclasts. Therefore, we suggest that drug repositioning of polaprezinc would be helpful for patients with fractures. |
format | Online Article Text |
id | pubmed-9110432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91104322022-05-18 Drug repositioning of polaprezinc for bone fracture healing Ko, Eun Ae Park, Yoo Jung Yoon, Dong Suk Lee, Kyoung-Mi Kim, Jihyun Jung, Sujin Lee, Jin Woo Park, Kwang Hwan Commun Biol Article Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential of mouse bone marrow-derived monocytes. In mouse experimental models with bone fractures, oral administration of polaprezinc accelerated fracture healing and maintained a high number of both osteoblasts and osteoclasts in the fracture areas. Collectively, polaprezinc promotes the fracture healing process efficiently by enhancing the activity of both osteoblasts and osteoclasts. Therefore, we suggest that drug repositioning of polaprezinc would be helpful for patients with fractures. Nature Publishing Group UK 2022-05-16 /pmc/articles/PMC9110432/ /pubmed/35577977 http://dx.doi.org/10.1038/s42003-022-03424-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ko, Eun Ae Park, Yoo Jung Yoon, Dong Suk Lee, Kyoung-Mi Kim, Jihyun Jung, Sujin Lee, Jin Woo Park, Kwang Hwan Drug repositioning of polaprezinc for bone fracture healing |
title | Drug repositioning of polaprezinc for bone fracture healing |
title_full | Drug repositioning of polaprezinc for bone fracture healing |
title_fullStr | Drug repositioning of polaprezinc for bone fracture healing |
title_full_unstemmed | Drug repositioning of polaprezinc for bone fracture healing |
title_short | Drug repositioning of polaprezinc for bone fracture healing |
title_sort | drug repositioning of polaprezinc for bone fracture healing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110432/ https://www.ncbi.nlm.nih.gov/pubmed/35577977 http://dx.doi.org/10.1038/s42003-022-03424-7 |
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