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Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we present an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially take place in HSCs with aging, whi...

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Detalles Bibliográficos
Autores principales:	Itokawa, Naoki, Oshima, Motohiko, Koide, Shuhei, Takayama, Naoya, Kuribayashi, Wakako, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Yamazaki, Satoshi, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Eto, Koji, Iwama, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110722/ https://www.ncbi.nlm.nih.gov/pubmed/35577813 http://dx.doi.org/10.1038/s41467-022-30440-2

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