The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations

Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to predict disea...

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Detalles Bibliográficos
Autores principales: Wang, Zhe, Choi, Shing Wan, Chami, Nathalie, Boerwinkle, Eric, Fornage, Myriam, Redline, Susan, Bis, Joshua C., Brody, Jennifer A., Psaty, Bruce M., Kim, Wonji, McDonald, Merry-Lynn N., Regan, Elizabeth A., Silverman, Edwin K., Liu, Ching-Ti, Vasan, Ramachandran S., Kalyani, Rita R., Mathias, Rasika A., Yanek, Lisa R., Arnett, Donna K., Justice, Anne E., North, Kari E., Kaplan, Robert, Heckbert, Susan R., de Andrade, Mariza, Guo, Xiuqing, Lange, Leslie A., Rich, Stephen S., Rotter, Jerome I., Ellinor, Patrick T., Lubitz, Steven A., Blangero, John, Shoemaker, M. Benjamin, Darbar, Dawood, Gladwin, Mark T., Albert, Christine M., Chasman, Daniel I., Jackson, Rebecca D., Kooperberg, Charles, Reiner, Alexander P., O’Reilly, Paul F., Loos, Ruth J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110787/
https://www.ncbi.nlm.nih.gov/pubmed/35592775
http://dx.doi.org/10.3389/fendo.2022.863893

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