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Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110816/ https://www.ncbi.nlm.nih.gov/pubmed/35592313 http://dx.doi.org/10.3389/fimmu.2022.889148 |
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author | Lambert, Nicolas El Moussaoui, Majdouline Ritacco, Caroline Moïse, Martin Paulus, Astrid Delvenne, Philippe Baron, Frédéric Sadzot, Bernard Maquet, Pierre |
author_facet | Lambert, Nicolas El Moussaoui, Majdouline Ritacco, Caroline Moïse, Martin Paulus, Astrid Delvenne, Philippe Baron, Frédéric Sadzot, Bernard Maquet, Pierre |
author_sort | Lambert, Nicolas |
collection | PubMed |
description | Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of immune checkpoint inhibitors in these complex situations. Here, we report a 66-year-old man who was concomitantly diagnosed with non-small cell lung cancer and progressive multifocal leukoencephalopathy. The patient was treated with anti-PD-L1 antibody atezolizumab, which allowed effective control of both lung cancer and progressive multifocal leukoencephalopathy, as demonstrated by the patient’s remarkable neurologic clinical improvement, JC viral load reduction in his cerebrospinal fluid, regression of the brain lesions visualized through MRI, and the strict radiological stability of his cancer. In parallel, treatment with atezolizumab was associated with biological evidence of T-cell reinvigoration. Hence, our data suggest that immune checkpoint inhibitors may constitute a treatment option for patients with cancer complicated by severe opportunistic infections. |
format | Online Article Text |
id | pubmed-9110816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91108162022-05-18 Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report Lambert, Nicolas El Moussaoui, Majdouline Ritacco, Caroline Moïse, Martin Paulus, Astrid Delvenne, Philippe Baron, Frédéric Sadzot, Bernard Maquet, Pierre Front Immunol Immunology Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of immune checkpoint inhibitors in these complex situations. Here, we report a 66-year-old man who was concomitantly diagnosed with non-small cell lung cancer and progressive multifocal leukoencephalopathy. The patient was treated with anti-PD-L1 antibody atezolizumab, which allowed effective control of both lung cancer and progressive multifocal leukoencephalopathy, as demonstrated by the patient’s remarkable neurologic clinical improvement, JC viral load reduction in his cerebrospinal fluid, regression of the brain lesions visualized through MRI, and the strict radiological stability of his cancer. In parallel, treatment with atezolizumab was associated with biological evidence of T-cell reinvigoration. Hence, our data suggest that immune checkpoint inhibitors may constitute a treatment option for patients with cancer complicated by severe opportunistic infections. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9110816/ /pubmed/35592313 http://dx.doi.org/10.3389/fimmu.2022.889148 Text en Copyright © 2022 Lambert, El Moussaoui, Ritacco, Moïse, Paulus, Delvenne, Baron, Sadzot and Maquet https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lambert, Nicolas El Moussaoui, Majdouline Ritacco, Caroline Moïse, Martin Paulus, Astrid Delvenne, Philippe Baron, Frédéric Sadzot, Bernard Maquet, Pierre Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title | Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title_full | Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title_fullStr | Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title_full_unstemmed | Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title_short | Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report |
title_sort | killing two birds with one stone: effective control of both non-small cell lung cancer and progressive multifocal leukoencephalopathy with atezolizumab, a case report |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110816/ https://www.ncbi.nlm.nih.gov/pubmed/35592313 http://dx.doi.org/10.3389/fimmu.2022.889148 |
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