Cargando…

Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report

Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of i...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambert, Nicolas, El Moussaoui, Majdouline, Ritacco, Caroline, Moïse, Martin, Paulus, Astrid, Delvenne, Philippe, Baron, Frédéric, Sadzot, Bernard, Maquet, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110816/
https://www.ncbi.nlm.nih.gov/pubmed/35592313
http://dx.doi.org/10.3389/fimmu.2022.889148
_version_ 1784709186364375040
author Lambert, Nicolas
El Moussaoui, Majdouline
Ritacco, Caroline
Moïse, Martin
Paulus, Astrid
Delvenne, Philippe
Baron, Frédéric
Sadzot, Bernard
Maquet, Pierre
author_facet Lambert, Nicolas
El Moussaoui, Majdouline
Ritacco, Caroline
Moïse, Martin
Paulus, Astrid
Delvenne, Philippe
Baron, Frédéric
Sadzot, Bernard
Maquet, Pierre
author_sort Lambert, Nicolas
collection PubMed
description Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of immune checkpoint inhibitors in these complex situations. Here, we report a 66-year-old man who was concomitantly diagnosed with non-small cell lung cancer and progressive multifocal leukoencephalopathy. The patient was treated with anti-PD-L1 antibody atezolizumab, which allowed effective control of both lung cancer and progressive multifocal leukoencephalopathy, as demonstrated by the patient’s remarkable neurologic clinical improvement, JC viral load reduction in his cerebrospinal fluid, regression of the brain lesions visualized through MRI, and the strict radiological stability of his cancer. In parallel, treatment with atezolizumab was associated with biological evidence of T-cell reinvigoration. Hence, our data suggest that immune checkpoint inhibitors may constitute a treatment option for patients with cancer complicated by severe opportunistic infections.
format Online
Article
Text
id pubmed-9110816
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91108162022-05-18 Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report Lambert, Nicolas El Moussaoui, Majdouline Ritacco, Caroline Moïse, Martin Paulus, Astrid Delvenne, Philippe Baron, Frédéric Sadzot, Bernard Maquet, Pierre Front Immunol Immunology Treating patients with cancer complicated by severe opportunistic infections is particularly challenging since classical cancer treatments, such as chemotherapy, often induce profound immune suppression and, as a result, may favor infection progression. Little is known about the potential place of immune checkpoint inhibitors in these complex situations. Here, we report a 66-year-old man who was concomitantly diagnosed with non-small cell lung cancer and progressive multifocal leukoencephalopathy. The patient was treated with anti-PD-L1 antibody atezolizumab, which allowed effective control of both lung cancer and progressive multifocal leukoencephalopathy, as demonstrated by the patient’s remarkable neurologic clinical improvement, JC viral load reduction in his cerebrospinal fluid, regression of the brain lesions visualized through MRI, and the strict radiological stability of his cancer. In parallel, treatment with atezolizumab was associated with biological evidence of T-cell reinvigoration. Hence, our data suggest that immune checkpoint inhibitors may constitute a treatment option for patients with cancer complicated by severe opportunistic infections. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9110816/ /pubmed/35592313 http://dx.doi.org/10.3389/fimmu.2022.889148 Text en Copyright © 2022 Lambert, El Moussaoui, Ritacco, Moïse, Paulus, Delvenne, Baron, Sadzot and Maquet https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lambert, Nicolas
El Moussaoui, Majdouline
Ritacco, Caroline
Moïse, Martin
Paulus, Astrid
Delvenne, Philippe
Baron, Frédéric
Sadzot, Bernard
Maquet, Pierre
Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title_full Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title_fullStr Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title_full_unstemmed Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title_short Killing Two Birds With One Stone: Effective Control of Both Non-Small Cell Lung Cancer and Progressive Multifocal Leukoencephalopathy With Atezolizumab, A Case Report
title_sort killing two birds with one stone: effective control of both non-small cell lung cancer and progressive multifocal leukoencephalopathy with atezolizumab, a case report
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110816/
https://www.ncbi.nlm.nih.gov/pubmed/35592313
http://dx.doi.org/10.3389/fimmu.2022.889148
work_keys_str_mv AT lambertnicolas killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT elmoussaouimajdouline killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT ritaccocaroline killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT moisemartin killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT paulusastrid killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT delvennephilippe killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT baronfrederic killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT sadzotbernard killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport
AT maquetpierre killingtwobirdswithonestoneeffectivecontrolofbothnonsmallcelllungcancerandprogressivemultifocalleukoencephalopathywithatezolizumabacasereport