Cargando…
Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study
Shugoshin-like protein 1 (SGO1) has been characterized in its function in correct cell division and its role in centrosome cohesion in the nucleus. However, the underlying biological function and potential mechanisms of SGO1 driving the progression of lung adenocarcinoma remain unclear. In this stud...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110828/ https://www.ncbi.nlm.nih.gov/pubmed/35592680 http://dx.doi.org/10.3389/fonc.2022.898920 |
_version_ | 1784709189455577088 |
---|---|
author | Yuan, Yixiao Wang, Juan Zhang, Dahang Tang, Lin Duan, Lincan Jiang, Xiulin |
author_facet | Yuan, Yixiao Wang, Juan Zhang, Dahang Tang, Lin Duan, Lincan Jiang, Xiulin |
author_sort | Yuan, Yixiao |
collection | PubMed |
description | Shugoshin-like protein 1 (SGO1) has been characterized in its function in correct cell division and its role in centrosome cohesion in the nucleus. However, the underlying biological function and potential mechanisms of SGO1 driving the progression of lung adenocarcinoma remain unclear. In this study, we found that SGO1 was increased in LUAD tissues and cell lines. Upregulation of SGO1 expression was correlated with poor overall survival (OS), disease-free survival (DSS), and progression-free survival (PFS) in patients with LUAD. ROC curve analysis suggested that the AUC value of SGO1 was 0.983. Correlation analysis showed that SGO1 expression was related to immune infiltration in LUAD. Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD. Finally, we determine that SGO1 regulated the cell proliferation and cell apoptosis of lung adenocarcinoma in vitro. In conclusion, our data suggested that SGO1 could be a novel prognostic biomarker for lung adenocarcinoma. |
format | Online Article Text |
id | pubmed-9110828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91108282022-05-18 Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study Yuan, Yixiao Wang, Juan Zhang, Dahang Tang, Lin Duan, Lincan Jiang, Xiulin Front Oncol Oncology Shugoshin-like protein 1 (SGO1) has been characterized in its function in correct cell division and its role in centrosome cohesion in the nucleus. However, the underlying biological function and potential mechanisms of SGO1 driving the progression of lung adenocarcinoma remain unclear. In this study, we found that SGO1 was increased in LUAD tissues and cell lines. Upregulation of SGO1 expression was correlated with poor overall survival (OS), disease-free survival (DSS), and progression-free survival (PFS) in patients with LUAD. ROC curve analysis suggested that the AUC value of SGO1 was 0.983. Correlation analysis showed that SGO1 expression was related to immune infiltration in LUAD. Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD. Finally, we determine that SGO1 regulated the cell proliferation and cell apoptosis of lung adenocarcinoma in vitro. In conclusion, our data suggested that SGO1 could be a novel prognostic biomarker for lung adenocarcinoma. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9110828/ /pubmed/35592680 http://dx.doi.org/10.3389/fonc.2022.898920 Text en Copyright © 2022 Yuan, Wang, Zhang, Tang, Duan and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Yuan, Yixiao Wang, Juan Zhang, Dahang Tang, Lin Duan, Lincan Jiang, Xiulin Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title | Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title_full | Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title_fullStr | Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title_full_unstemmed | Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title_short | Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis and In Vitro Study |
title_sort | deciphering the role of shugoshin-like protein 1 in lung adenocarcinoma: a comprehensive analysis and in vitro study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110828/ https://www.ncbi.nlm.nih.gov/pubmed/35592680 http://dx.doi.org/10.3389/fonc.2022.898920 |
work_keys_str_mv | AT yuanyixiao decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy AT wangjuan decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy AT zhangdahang decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy AT tanglin decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy AT duanlincan decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy AT jiangxiulin decipheringtheroleofshugoshinlikeprotein1inlungadenocarcinomaacomprehensiveanalysisandinvitrostudy |