Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia

BACKGROUND: Ischemic stroke is one of the leading causes of human death and disability. Brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both involving aquaporin-4 (AQP4). Studies revealed that acute inhibition of AQP4 after stroke diminishes brain edema, however,...

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Detalles Bibliográficos
Autores principales: Sun, Chengfeng, Lin, Luyi, Yin, Lekang, Hao, Xiaozhu, Tian, Jiaqi, Zhang, Xiaoxue, Ren, Yan, Li, Chanchan, Yang, Yanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110854/
https://www.ncbi.nlm.nih.gov/pubmed/35592320
http://dx.doi.org/10.3389/fimmu.2022.870029

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