Cargando…

Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation

Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases. Interleukin (IL)-15 is a key factor for natural killer cells (NK) and CD8 T cells homeostasi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meghnem, Dihia, Maillasson, Mike, Barbieux, Isabelle, Morisseau, Sébastien, Keita, Dalloba, Jacques, Yannick, Quéméner, Agnès, Mortier, Erwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110858/ https://www.ncbi.nlm.nih.gov/pubmed/35592318 http://dx.doi.org/10.3389/fimmu.2022.886213

Ejemplares similares

Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations
por: Sousa, Rui P., et al.
Publicado: (2019)

Antitumor activity of an immunocytokine composed of an anti-GD2 antibody and the IL-15 superagonist RLI
por: Vincent, Marie, et al.
Publicado: (2013)

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
por: Mortier, Erwan, et al.
Publicado: (2008)

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
por: Huntington, Nicholas D., et al.
Publicado: (2009)

Toll‐like receptor 2 activation induces C–C chemokine receptor 2‐dependent natural killer cell recruitment to the peritoneum
por: Haidl, Ian D, et al.
Publicado: (2020)

Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation
por: Meghnem, Dihia, et al.
Publicado: (2022)

Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
por: Meghnem, Dihia, et al.
Publicado: (2021)

79696 Reversible DNA Hypermethylation of the Interleukin-15 Promoter Induces IL-15 Expression, Drives the Pathogenesis of T-Cell Large Granular Lymphocytic Leukemia (T-LGLL) and Provides a Therapeutic Approach Using 5-Azacitidine
por: Brammer, Jonathan E, et al.
Publicado: (2021)

Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity
por: Van den Bergh, Johan, et al.
Publicado: (2015)

Adoptive transfer of IL-4Rα(+ )macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
por: Ford, Andrew Q, et al.
Publicado: (2012)

Antibody-Hapten Recognition at the Surface of Functionalized Liposomes Studied by SPR: Steric Hindrance of Pegylated Phospholipids in Stealth Liposomes Prepared for Targeted Radionuclide Delivery
por: Botosoa, Eliot. P., et al.
Publicado: (2011)

The roles of different forms of IL-15 in human melanoma progression
por: Di Matteo, Sabina, et al.
Publicado: (2023)

IL-15/IL-15Rα in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin
por: Bellón, Teresa, et al.
Publicado: (2022)

Electrotransfer of IL-15/IL-15Rα complex for the treatment of established melanoma
por: Shirley, Shawna, et al.
Publicado: (2015)

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma
por: Shirley, Shawna A., et al.
Publicado: (2020)

Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation
por: Swaminathan, Sanjay, et al.
Publicado: (2016)

Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man
por: Bouchaud, Grégory, et al.
Publicado: (2013)

Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner
por: Anguille, Sébastien, et al.
Publicado: (2015)

From Sufficient Health to Sufficient Responsibility
por: Davies, Ben, et al.
Publicado: (2020)

Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung
por: Battistoni, Arthur, et al.
Publicado: (2023)

Is retrieval of at least 15 lymph nodes sufficient recommendation in early gastric cancer?
por: Kim, Yong Il
Publicado: (2014)

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
Publicado: (1996)

hnRNP‐A1 binds to the IRES of MELOE‐1 antigen to promote MELOE‐1 translation in stressed melanoma cells
por: Charpentier, Maud, et al.
Publicado: (2021)

NK Cell Hyporesponsiveness: More Is Not Always Better
por: Frutoso, Marie, et al.
Publicado: (2019)

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment
por: Desbois, Mélanie, et al.
Publicado: (2020)

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models
por: Guo, Siqi, et al.
Publicado: (2021)

A novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapy
por: Xu, Hong, et al.
Publicado: (2021)

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4(+) T Cells
por: Ridley, Michael L., et al.
Publicado: (2020)

Interleukin-15 and cancer: some solved and many unsolved questions
por: Fiore, Piera Filomena, et al.
Publicado: (2020)

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4(+) T cells
por: Awad, Robin Maximilian, et al.
Publicado: (2023)

12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice
por: Miyata, Jun, et al.
Publicado: (2021)

High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner
por: Polansky, Julia K., et al.
Publicado: (2016)

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice
por: Koka, Rima, et al.
Publicado: (2003)

Vaccination with Tumor Cells Expressing IL-15 and IL-15Rα Inhibit Murine Breast and Prostate Cancer
por: Morris, John C., et al.
Publicado: (2014)

The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse
por: Moui, Antoine, et al.
Publicado: (2020)

Selective costimulation by IL-15R/IL-15, but not IL-2R/IL-2, allows the induction of high numbers of tumor-specific CD8+ T cells by human dendritic cells matured in conditions of acute inflammation
por: Hansen, Morten, et al.
Publicado: (2015)

Covert Attention to Gestures Is Sufficient for Information Uptake
por: Kandana Arachchige, Kendra Gimhani, et al.
Publicado: (2021)

An activation-induced IL-15 isoform is a natural antagonist for IL-15 function
por: Zhao, Lei, et al.
Publicado: (2016)

Is decolonisation sufficient?
por: Contractor, Sana Qais, et al.
Publicado: (2022)

NK Cell Activation in Human Hantavirus Infection Explained by Virus-Induced IL-15/IL15Rα Expression
por: Braun, Monika, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_b3m89cco0ohp0gpj7d8vut7jod