Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis

Free amino acids that accumulate in the plasma of patients with diabetes and obesity influence lipid metabolism and protein synthesis in the liver. The stress-inducible intracellular protease calpain proteolyzes various substrates in vascular endothelial cells (ECs), although its contribution to the...

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Detalles Bibliográficos
Autores principales: Akasu, Risako, Miyazaki, Takuro, Elhussiny, Mohamed Z., Sugiura, Yuki, Tomitsuka, Yuki, Haraguchi, Shogo, Otsu, Kinya, Chowdhury, Vishwajit S., Miyazaki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110893/
https://www.ncbi.nlm.nih.gov/pubmed/35447117
http://dx.doi.org/10.1016/j.jbc.2022.101953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110893/
https://www.ncbi.nlm.nih.gov/pubmed/35447117
http://dx.doi.org/10.1016/j.jbc.2022.101953

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