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The Use of Probiotic Therapy in Metabolic and Neurological Diseases
The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut m...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110960/ https://www.ncbi.nlm.nih.gov/pubmed/35592636 http://dx.doi.org/10.3389/fnut.2022.887019 |
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author | Lee, Shirley H. F. Ahmad, Siti R. Lim, Ya C. Zulkipli, Ihsan N. |
author_facet | Lee, Shirley H. F. Ahmad, Siti R. Lim, Ya C. Zulkipli, Ihsan N. |
author_sort | Lee, Shirley H. F. |
collection | PubMed |
description | The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut microbiome and may be used for therapeutic purposes in diseases where dysbioses in the gut microbiome have been shown are of particular interest. This review compiles current evidence available in the scientific literature on the use of probiotics to treat metabolic diseases and autism spectrum disorders (ASDs) to analyze the efficacy of probiotics in these diseases. To do this, we must first define the healthy gut microbiome before looking at the interplay between the gut microbiome and diseases, and how probiotics affect this interaction. In metabolic diseases, such as obesity and diabetes, probiotic supplementation positively impacts pathological parameters. Conversely, the gut–brain axis significantly impacts neurodevelopmental disorders such as ASDs. However, manipulating the gut microbiome and disease symptoms using probiotics has less pronounced effects on neurodevelopmental diseases. This may be due to a more complex interplay between genetics and the environment in these diseases. In conclusion, the use of microbe-based probiotic therapy may potentially have beneficial effects in ameliorating the pathology of various diseases. Validation of available data for the development of personalized treatment regimens for affected patients is still required. |
format | Online Article Text |
id | pubmed-9110960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91109602022-05-18 The Use of Probiotic Therapy in Metabolic and Neurological Diseases Lee, Shirley H. F. Ahmad, Siti R. Lim, Ya C. Zulkipli, Ihsan N. Front Nutr Nutrition The human gut is home to trillions of microbes that interact with host cells to influence and contribute to body functions. The number of scientific studies focusing on the gut microbiome has exponentially increased in recent years. Studies investigating factors that may potentially affect the gut microbiome and may be used for therapeutic purposes in diseases where dysbioses in the gut microbiome have been shown are of particular interest. This review compiles current evidence available in the scientific literature on the use of probiotics to treat metabolic diseases and autism spectrum disorders (ASDs) to analyze the efficacy of probiotics in these diseases. To do this, we must first define the healthy gut microbiome before looking at the interplay between the gut microbiome and diseases, and how probiotics affect this interaction. In metabolic diseases, such as obesity and diabetes, probiotic supplementation positively impacts pathological parameters. Conversely, the gut–brain axis significantly impacts neurodevelopmental disorders such as ASDs. However, manipulating the gut microbiome and disease symptoms using probiotics has less pronounced effects on neurodevelopmental diseases. This may be due to a more complex interplay between genetics and the environment in these diseases. In conclusion, the use of microbe-based probiotic therapy may potentially have beneficial effects in ameliorating the pathology of various diseases. Validation of available data for the development of personalized treatment regimens for affected patients is still required. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9110960/ /pubmed/35592636 http://dx.doi.org/10.3389/fnut.2022.887019 Text en Copyright © 2022 Lee, Ahmad, Lim and Zulkipli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Lee, Shirley H. F. Ahmad, Siti R. Lim, Ya C. Zulkipli, Ihsan N. The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title | The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title_full | The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title_fullStr | The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title_full_unstemmed | The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title_short | The Use of Probiotic Therapy in Metabolic and Neurological Diseases |
title_sort | use of probiotic therapy in metabolic and neurological diseases |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110960/ https://www.ncbi.nlm.nih.gov/pubmed/35592636 http://dx.doi.org/10.3389/fnut.2022.887019 |
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