GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

Inborn errors of immunity (IEIs) unveil regulatory pathways of human immunity. We describe a new IEI caused by mutations in the GTPase of the immune-associated protein 6 (GIMAP6) gene in patients with infections, lymphoproliferation, autoimmunity, and multiorgan vasculitis. Patients and Gimap6(−/−)...

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Autores principales: Yao, Yikun, Du Jiang, Ping, Chao, Brittany N., Cagdas, Deniz, Kubo, Satoshi, Balasubramaniyam, Arasu, Zhang, Yu, Shadur, Bella, NaserEddin, Adeeb, Folio, Les R., Schwarz, Benjamin, Bohrnsen, Eric, Zheng, Lixin, Lynberg, Matthew, Gottlieb, Simone, Leney-Greene, Michael A., Park, Ann Y., Tezcan, Ilhan, Akdogan, Ali, Gocmen, Rahsan, Onder, Sevgen, Rosenberg, Avi, Soilleux, Elizabeth J., Johnson, Errin, Jackson, Peter K., Demeter, Janos, Chauvin, Samuel D., Paul, Florian, Selbach, Matthias, Bulut, Haydar, Clatworthy, Menna R., Tuong, Zewen K., Zhang, Hanlin, Stewart, Benjamin J., Bosio, Catharine M., Stepensky, Polina, Clare, Simon, Ganesan, Sundar, Pascall, John C., Daumke, Oliver, Butcher, Geoffrey W., McMichael, Andrew J., Simon, Anna Katharina, Lenardo, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111091/
https://www.ncbi.nlm.nih.gov/pubmed/35551368
http://dx.doi.org/10.1084/jem.20201405

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