Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease

Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Jaime, Patricio, Felipe, Patricio-Martínez, Aleidy, Santos-López, Gerardo, Cedillo, Lilia, Tizabi, Yousef, Limón, Ilhuicamina Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111171/
https://www.ncbi.nlm.nih.gov/pubmed/35592266
http://dx.doi.org/10.3389/fnins.2022.867825
_version_ 1784709243561050112
author Silva, Jaime
Patricio, Felipe
Patricio-Martínez, Aleidy
Santos-López, Gerardo
Cedillo, Lilia
Tizabi, Yousef
Limón, Ilhuicamina Daniel
author_facet Silva, Jaime
Patricio, Felipe
Patricio-Martínez, Aleidy
Santos-López, Gerardo
Cedillo, Lilia
Tizabi, Yousef
Limón, Ilhuicamina Daniel
author_sort Silva, Jaime
collection PubMed
description Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is argued that SARS-Cov-2-induced cytokine storm, neuroinflammation and oxidative stress increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Further studies on the effects of SARS-CoV-2 and its variants on protein aggregation, glia or microglia activation, and blood-brain barrier are warranted.
format Online
Article
Text
id pubmed-9111171
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91111712022-05-18 Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease Silva, Jaime Patricio, Felipe Patricio-Martínez, Aleidy Santos-López, Gerardo Cedillo, Lilia Tizabi, Yousef Limón, Ilhuicamina Daniel Front Neurosci Neuroscience Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is argued that SARS-Cov-2-induced cytokine storm, neuroinflammation and oxidative stress increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Further studies on the effects of SARS-CoV-2 and its variants on protein aggregation, glia or microglia activation, and blood-brain barrier are warranted. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9111171/ /pubmed/35592266 http://dx.doi.org/10.3389/fnins.2022.867825 Text en Copyright © 2022 Silva, Patricio, Patricio-Martínez, Santos-López, Cedillo, Tizabi and Limón. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Silva, Jaime
Patricio, Felipe
Patricio-Martínez, Aleidy
Santos-López, Gerardo
Cedillo, Lilia
Tizabi, Yousef
Limón, Ilhuicamina Daniel
Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title_full Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title_fullStr Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title_full_unstemmed Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title_short Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease
title_sort neuropathological aspects of sars-cov-2 infection: significance for both alzheimer’s and parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111171/
https://www.ncbi.nlm.nih.gov/pubmed/35592266
http://dx.doi.org/10.3389/fnins.2022.867825
work_keys_str_mv AT silvajaime neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT patriciofelipe neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT patriciomartinezaleidy neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT santoslopezgerardo neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT cedillolilia neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT tizabiyousef neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease
AT limonilhuicaminadaniel neuropathologicalaspectsofsarscov2infectionsignificanceforbothalzheimersandparkinsonsdisease

Ejemplares similares