COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis

COVID‐19 vaccination effectiveness has been monitored in observational studies (test‐negativity design or traditional cohort design), but these studies have not addressed the potential behavioral bias between vaccinated and unvaccinated individuals. We aimed to address this by comparing COVID‐19 tes...

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Autores principales: Kuitunen, Ilari, Uimonen, Mikko, Seppälä, Santeri J., Ponkilainen, Ville T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111451/
https://www.ncbi.nlm.nih.gov/pubmed/35475567
http://dx.doi.org/10.1111/irv.12993
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author Kuitunen, Ilari
Uimonen, Mikko
Seppälä, Santeri J.
Ponkilainen, Ville T.
author_facet Kuitunen, Ilari
Uimonen, Mikko
Seppälä, Santeri J.
Ponkilainen, Ville T.
author_sort Kuitunen, Ilari
collection PubMed
description COVID‐19 vaccination effectiveness has been monitored in observational studies (test‐negativity design or traditional cohort design), but these studies have not addressed the potential behavioral bias between vaccinated and unvaccinated individuals. We aimed to address this by comparing COVID‐19 testing rates between vaccination status and whether vaccination changes the testing rates. We found that three times vaccinated had least tests performed during the pandemic and unvaccinated had the highest testing rate. Each vaccination dose increased the testing rate. In conclusion the observational studies addressing vaccine effectiveness should also present testing rates between vaccinated and unvaccinated to address the potential behavioral bias.
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spelling pubmed-91114512022-05-17 COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis Kuitunen, Ilari Uimonen, Mikko Seppälä, Santeri J. Ponkilainen, Ville T. Influenza Other Respir Viruses Short Communications COVID‐19 vaccination effectiveness has been monitored in observational studies (test‐negativity design or traditional cohort design), but these studies have not addressed the potential behavioral bias between vaccinated and unvaccinated individuals. We aimed to address this by comparing COVID‐19 testing rates between vaccination status and whether vaccination changes the testing rates. We found that three times vaccinated had least tests performed during the pandemic and unvaccinated had the highest testing rate. Each vaccination dose increased the testing rate. In conclusion the observational studies addressing vaccine effectiveness should also present testing rates between vaccinated and unvaccinated to address the potential behavioral bias. John Wiley and Sons Inc. 2022-04-27 2022-09 /pmc/articles/PMC9111451/ /pubmed/35475567 http://dx.doi.org/10.1111/irv.12993 Text en © 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Kuitunen, Ilari
Uimonen, Mikko
Seppälä, Santeri J.
Ponkilainen, Ville T.
COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title_full COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title_fullStr COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title_full_unstemmed COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title_short COVID‐19 vaccination status and testing rates in Finland—A potential cause for bias in observational vaccine effectiveness analysis
title_sort covid‐19 vaccination status and testing rates in finland—a potential cause for bias in observational vaccine effectiveness analysis
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111451/
https://www.ncbi.nlm.nih.gov/pubmed/35475567
http://dx.doi.org/10.1111/irv.12993
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