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Antigen binding by conformational selection in near-germline antibodies

Conformational flexibility in antibody-combining sites has been hypothesized to facilitate polyspecificity toward multiple unique epitopes and enable the limited germline repertoire to match an overwhelming diversity of potential antigens; however, elucidating the mechanisms of antigen recognition b...

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Detalles Bibliográficos
Autores principales:	Blackler, Ryan J., Müller-Loennies, Sven, Pokorny-Lehrer, Barbara, Legg, Max S.G., Brade, Lore, Brade, Helmut, Kosma, Paul, Evans, Stephen V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112003/ https://www.ncbi.nlm.nih.gov/pubmed/35395245 http://dx.doi.org/10.1016/j.jbc.2022.101901

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