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REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112011/ https://www.ncbi.nlm.nih.gov/pubmed/35592144 http://dx.doi.org/10.1016/j.nbscr.2022.100076 |
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author | Renouard, Leslie Hayworth, Christopher Rempe, Michael Clegern, Will Wisor, Jonathan Frank, Marcos G. |
author_facet | Renouard, Leslie Hayworth, Christopher Rempe, Michael Clegern, Will Wisor, Jonathan Frank, Marcos G. |
author_sort | Renouard, Leslie |
collection | PubMed |
description | Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been explored in only one class of cortical neuron (layer 5 apical dendrites). We investigated the role of REM sleep in ocular dominance plasticity (ODP) in layer 2/3 neurons using 2-photon calcium imaging in awake CP mice. In contrast to findings in layer 5 neurons, we find that REM sleep promotes changes consistent with synaptic strengthening and weakening. This supports recent suggestions that the effects of sleep on plasticity are highly dependent upon the type of circuit and preceding waking experience. |
format | Online Article Text |
id | pubmed-9112011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-91120112022-05-18 REM sleep promotes bidirectional plasticity in developing visual cortex in vivo Renouard, Leslie Hayworth, Christopher Rempe, Michael Clegern, Will Wisor, Jonathan Frank, Marcos G. Neurobiol Sleep Circadian Rhythms Short Communication Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been explored in only one class of cortical neuron (layer 5 apical dendrites). We investigated the role of REM sleep in ocular dominance plasticity (ODP) in layer 2/3 neurons using 2-photon calcium imaging in awake CP mice. In contrast to findings in layer 5 neurons, we find that REM sleep promotes changes consistent with synaptic strengthening and weakening. This supports recent suggestions that the effects of sleep on plasticity are highly dependent upon the type of circuit and preceding waking experience. Elsevier 2022-05-04 /pmc/articles/PMC9112011/ /pubmed/35592144 http://dx.doi.org/10.1016/j.nbscr.2022.100076 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Communication Renouard, Leslie Hayworth, Christopher Rempe, Michael Clegern, Will Wisor, Jonathan Frank, Marcos G. REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title | REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title_full | REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title_fullStr | REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title_full_unstemmed | REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title_short | REM sleep promotes bidirectional plasticity in developing visual cortex in vivo |
title_sort | rem sleep promotes bidirectional plasticity in developing visual cortex in vivo |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112011/ https://www.ncbi.nlm.nih.gov/pubmed/35592144 http://dx.doi.org/10.1016/j.nbscr.2022.100076 |
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