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REM sleep promotes bidirectional plasticity in developing visual cortex in vivo

Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been e...

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Detalles Bibliográficos
Autores principales: Renouard, Leslie, Hayworth, Christopher, Rempe, Michael, Clegern, Will, Wisor, Jonathan, Frank, Marcos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112011/
https://www.ncbi.nlm.nih.gov/pubmed/35592144
http://dx.doi.org/10.1016/j.nbscr.2022.100076
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author Renouard, Leslie
Hayworth, Christopher
Rempe, Michael
Clegern, Will
Wisor, Jonathan
Frank, Marcos G.
author_facet Renouard, Leslie
Hayworth, Christopher
Rempe, Michael
Clegern, Will
Wisor, Jonathan
Frank, Marcos G.
author_sort Renouard, Leslie
collection PubMed
description Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been explored in only one class of cortical neuron (layer 5 apical dendrites). We investigated the role of REM sleep in ocular dominance plasticity (ODP) in layer 2/3 neurons using 2-photon calcium imaging in awake CP mice. In contrast to findings in layer 5 neurons, we find that REM sleep promotes changes consistent with synaptic strengthening and weakening. This supports recent suggestions that the effects of sleep on plasticity are highly dependent upon the type of circuit and preceding waking experience.
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spelling pubmed-91120112022-05-18 REM sleep promotes bidirectional plasticity in developing visual cortex in vivo Renouard, Leslie Hayworth, Christopher Rempe, Michael Clegern, Will Wisor, Jonathan Frank, Marcos G. Neurobiol Sleep Circadian Rhythms Short Communication Sleep is required for the full expression of plasticity during the visual critical period (CP). However, the precise role of rapid-eye-movement (REM) sleep in this process is undetermined. Previous studies in rodents indicate that REM sleep weakens cortical circuits following MD, but this has been explored in only one class of cortical neuron (layer 5 apical dendrites). We investigated the role of REM sleep in ocular dominance plasticity (ODP) in layer 2/3 neurons using 2-photon calcium imaging in awake CP mice. In contrast to findings in layer 5 neurons, we find that REM sleep promotes changes consistent with synaptic strengthening and weakening. This supports recent suggestions that the effects of sleep on plasticity are highly dependent upon the type of circuit and preceding waking experience. Elsevier 2022-05-04 /pmc/articles/PMC9112011/ /pubmed/35592144 http://dx.doi.org/10.1016/j.nbscr.2022.100076 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Renouard, Leslie
Hayworth, Christopher
Rempe, Michael
Clegern, Will
Wisor, Jonathan
Frank, Marcos G.
REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title_full REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title_fullStr REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title_full_unstemmed REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title_short REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
title_sort rem sleep promotes bidirectional plasticity in developing visual cortex in vivo
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112011/
https://www.ncbi.nlm.nih.gov/pubmed/35592144
http://dx.doi.org/10.1016/j.nbscr.2022.100076
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