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Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

CasRx, a recently discovered member of the type VI CRISPR system with minimum size, offers a new approach for RNA manipulation with high efficiency and specificity in prokaryotes and eukaryotes. However, in vivo studies of functional recovery using the CasRx system have not been well characterized....

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Detalles Bibliográficos
Autores principales:	Guo, Yang, Han, Lei, Han, Shuang, Tang, Honghai, Wang, Shengyi, Cui, Chong, Chen, Bing, Li, Huawei, Shu, Yilai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112053/ https://www.ncbi.nlm.nih.gov/pubmed/35615000 http://dx.doi.org/10.1016/j.omtn.2022.04.014

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