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The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()

BACKGROUND: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerv...

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Autores principales: Sijben, Laura C.J., Mess, Werner H., Walter, Uwe, Janssen, A. Miranda L., L. Kuijf, Mark, Oosterloo, Mayke, Weber, Wim E.J.., Janssen, Marcus L.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112122/
https://www.ncbi.nlm.nih.gov/pubmed/35592106
http://dx.doi.org/10.1016/j.ensci.2022.100400
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author Sijben, Laura C.J.
Mess, Werner H.
Walter, Uwe
Janssen, A. Miranda L.
L. Kuijf, Mark
Oosterloo, Mayke
Weber, Wim E.J..
Janssen, Marcus L.F.
author_facet Sijben, Laura C.J.
Mess, Werner H.
Walter, Uwe
Janssen, A. Miranda L.
L. Kuijf, Mark
Oosterloo, Mayke
Weber, Wim E.J..
Janssen, Marcus L.F.
author_sort Sijben, Laura C.J.
collection PubMed
description BACKGROUND: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants. METHODS: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound. RESULTS: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve. CONCLUSION: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD.
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spelling pubmed-91121222022-05-18 The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients() Sijben, Laura C.J. Mess, Werner H. Walter, Uwe Janssen, A. Miranda L. L. Kuijf, Mark Oosterloo, Mayke Weber, Wim E.J.. Janssen, Marcus L.F. eNeurologicalSci Original Article BACKGROUND: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants. METHODS: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound. RESULTS: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve. CONCLUSION: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD. Elsevier 2022-05-05 /pmc/articles/PMC9112122/ /pubmed/35592106 http://dx.doi.org/10.1016/j.ensci.2022.100400 Text en © 2022 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Sijben, Laura C.J.
Mess, Werner H.
Walter, Uwe
Janssen, A. Miranda L.
L. Kuijf, Mark
Oosterloo, Mayke
Weber, Wim E.J..
Janssen, Marcus L.F.
The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title_full The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title_fullStr The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title_full_unstemmed The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title_short The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients()
title_sort cross-sectional area of the vagus nerve is not reduced in parkinson's disease patients()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112122/
https://www.ncbi.nlm.nih.gov/pubmed/35592106
http://dx.doi.org/10.1016/j.ensci.2022.100400
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