Cargando…

Evaluation of Phenol-Substituted Diphyllin Derivatives as Selective Antagonists for Ebola Virus Entry

[Image: see text] Ebola virus (EBOV) is an aggressive filoviral pathogen that can induce severe hemorrhagic fever in humans with up to 90% fatality rate. To date, there are no clinically effective small-molecule drugs for postexposure therapies to treat filoviral infections. EBOV cellular entry and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plescia, Caroline B., Lindstrom, Aaron R., Quintero, Maritza V., Keiser, Patrick, Anantpadma, Manu, Davey, Robert, Stahelin, Robert V., Davisson, V. Jo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112336/ https://www.ncbi.nlm.nih.gov/pubmed/35357134 http://dx.doi.org/10.1021/acsinfecdis.1c00474

Ejemplares similares

Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus
por: Cui, Qinghua, et al.
Publicado: (2018)

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor
por: Cui, Qinghua, et al.
Publicado: (2018)

Machine learning models identify molecules active against the Ebola virus in vitro
por: Ekins, Sean, et al.
Publicado: (2017)

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus
por: Martinez-Lopez, Alicia, et al.
Publicado: (2019)

Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID(50) Assays
por: Keiser, Patrick T., et al.
Publicado: (2021)

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection
por: Lane, Thomas R., et al.
Publicado: (2019)

Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses
por: Chen, Hui-Wen, et al.
Publicado: (2013)

Membrane binding and bending in Ebola VP40 assembly and egress
por: Stahelin, Robert V.
Publicado: (2014)

The Ebola Virus: From Basic Research to a Global Health Crisis
por: Stahelin, Robert V.
Publicado: (2015)

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads
por: Anantpadma, Manu, et al.
Publicado: (2019)

Interferon-γ Inhibits Ebola Virus Infection
por: Rhein, Bethany A., et al.
Publicado: (2015)

SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles
por: Plescia, Caroline B., et al.
Publicado: (2020)

Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
por: Stefanik, Michal, et al.
Publicado: (2021)

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties
por: Su, Yuan, et al.
Publicado: (2020)

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding
por: Husby, Monica L, et al.
Publicado: (2022)

Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells
por: Chen, Haijiao, et al.
Publicado: (2018)

Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
por: Duan, Ya-Nan, et al.
Publicado: (2020)

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus
por: Saeed, Mohammad F., et al.
Publicado: (2008)

Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses
por: Štefánik, Michal, et al.
Publicado: (2022)

Evaluation of Fendiline Treatment in VP40 System with Nucleation-Elongation Process: A Computational Model of Ebola Virus Matrix Protein Assembly
por: Liu, Xiao, et al.
Publicado: (2023)

Analysis of Ebola Virus Entry Into Macrophages
por: Dahlmann, Franziska, et al.
Publicado: (2015)

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A
por: Smulders, Larissa, et al.
Publicado: (2020)

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes
por: Saeed, Mohammad F., et al.
Publicado: (2010)

Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly
por: Liu, Xiao, et al.
Publicado: (2022)

A Loop Region in the N-Terminal Domain of Ebola Virus VP40 Is Important in Viral Assembly, Budding, and Egress
por: Adu-Gyamfi, Emmanuel, et al.
Publicado: (2014)

Chemical and Structural Aspects of Ebola Virus Entry Inhibitors
por: Nyakatura, Elisabeth K., et al.
Publicado: (2014)

Qualitative study of Ebola screening at ports of entry to the UK
por: Kesten, Joanna May, et al.
Publicado: (2018)

HER2-mediated enhancement of Ebola virus entry
por: Kuroda, Makoto, et al.
Publicado: (2020)

Ebola Entry Inhibitors Discovered from Maesa perlarius
por: Tsang, Nga Yi, et al.
Publicado: (2022)

A Conserved Tryptophan in the Ebola Virus Matrix Protein C-Terminal Domain Is Required for Efficient Virus-Like Particle Formation
por: Johnson, Kristen A., et al.
Publicado: (2020)

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) for extensive oligomerization at the plasma membrane and viral egress
por: Johnson, Kristen A., et al.
Publicado: (2016)

Ebola Virus Entry: A Curious and Complex Series of Events
por: Moller-Tank, Sven, et al.
Publicado: (2015)

Ebola Virus Entry into Host Cells: Identifying Therapeutic Strategies
por: Rhein, Bethany A., et al.
Publicado: (2015)

Ebola Virus Entry: From Molecular Characterization to Drug Discovery
por: Salata, Cristiano, et al.
Publicado: (2019)

Characterization of the receptor-binding domain of Ebola glycoprotein in viral entry
por: Wang, Jizhen, et al.
Publicado: (2011)

A review on the antagonist Ebola: A prophylactic approach
por: Khan, Fatima Nazish, et al.
Publicado: (2017)

Inactivation of Ebola Virus and SARS-CoV-2 in Cell Culture Supernatants and Cell Pellets by Gamma Irradiation
por: Boytz, RuthMabel, et al.
Publicado: (2022)

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes
por: Miller, Emily Happy, et al.
Publicado: (2011)

The role of the charged residues of the GP2 helical regions in Ebola entry
por: Jiang, Haiqing, et al.
Publicado: (2009)

Airport Exit and Entry Screening for Ebola — August–November 10, 2014
por: Brown, Clive M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fc9n2i3ln0p2fa8hpdv806083c