Incidence and risk factors of perioperative venous thromboembolism in patients with cervical cancer

The aim of this retrospective study was to identify the perioperative incidence and risk factors of venous thromboembolism (VTE) in patients undergoing surgery for cervical cancer. The retrospective medical records of consecutive patients with cervical cancer were collected at the Qianfoshan Hospital affiliated with Shandong University from July 2014 to July 2017. Basic information regarding the patients, as well as tumor and surgery-related factors were compared between the cervical cancer patients with and without VTE. In the present study, a total of 338 patients undergoing surgery for cervical cancer were included. Ten (3.0%) patients were diagnosed with preoperative VTE and 18 (5.5%) with postoperative VTE. Multivariate analyses found that high levels of D-dimer and a larger size of the cervical tumor were independent risk factors for preoperative VTE, whereas the length of surgery and use of chemotherapy were independently associated with VTE development within 30 days after surgery. In conclusion, the major findings of the present study was a significant incidence of VTE in patients with cervical cancer. We also identified the clinical characteristics which can cause cervical cancer patients to have an increased risk for VTE.