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Infertility and risk of breast cancer in men: a national case–control study in England and Wales

PURPOSE: Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case–control study, the...

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Autores principales: Swerdlow, Anthony J., Bruce, Cydney, Cooke, Rosie, Coulson, Penny, Jones, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112475/
https://www.ncbi.nlm.nih.gov/pubmed/35578306
http://dx.doi.org/10.1186/s13058-022-01517-z
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author Swerdlow, Anthony J.
Bruce, Cydney
Cooke, Rosie
Coulson, Penny
Jones, Michael E.
author_facet Swerdlow, Anthony J.
Bruce, Cydney
Cooke, Rosie
Coulson, Penny
Jones, Michael E.
author_sort Swerdlow, Anthony J.
collection PubMed
description PURPOSE: Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case–control study, the relation of risk of breast cancer in men to infertility and number of children. PATIENTS AND METHODS: We conducted a national case–control study in England and Wales, interviewing 1998 cases incident 2005–17 and 1597 male controls, which included questions on infertility and offspring. RESULTS: Risk of breast cancer was statistically significantly associated with male-origin infertility (OR = 2.03 (95% confidence interval (CI) 1.18–3.49)) but not if a couple’s infertility had been diagnosed as of origin from the female partner (OR = 0.86 (0.51–1.45)). Risk was statistically significantly raised for men who had not fathered any children (OR = 1.50 (95% CI 1.21–1.86)) compared with men who were fathers. These associations were statistically significantly present for invasive tumours but not statistically significant for in situ tumours. CONCLUSION: Our data give strong evidence that risk of breast cancer is increased for men who are infertile. The reason is not clear and needs investigation.
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spelling pubmed-91124752022-05-18 Infertility and risk of breast cancer in men: a national case–control study in England and Wales Swerdlow, Anthony J. Bruce, Cydney Cooke, Rosie Coulson, Penny Jones, Michael E. Breast Cancer Res Research Article PURPOSE: Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case–control study, the relation of risk of breast cancer in men to infertility and number of children. PATIENTS AND METHODS: We conducted a national case–control study in England and Wales, interviewing 1998 cases incident 2005–17 and 1597 male controls, which included questions on infertility and offspring. RESULTS: Risk of breast cancer was statistically significantly associated with male-origin infertility (OR = 2.03 (95% confidence interval (CI) 1.18–3.49)) but not if a couple’s infertility had been diagnosed as of origin from the female partner (OR = 0.86 (0.51–1.45)). Risk was statistically significantly raised for men who had not fathered any children (OR = 1.50 (95% CI 1.21–1.86)) compared with men who were fathers. These associations were statistically significantly present for invasive tumours but not statistically significant for in situ tumours. CONCLUSION: Our data give strong evidence that risk of breast cancer is increased for men who are infertile. The reason is not clear and needs investigation. BioMed Central 2022-05-17 2022 /pmc/articles/PMC9112475/ /pubmed/35578306 http://dx.doi.org/10.1186/s13058-022-01517-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Swerdlow, Anthony J.
Bruce, Cydney
Cooke, Rosie
Coulson, Penny
Jones, Michael E.
Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title_full Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title_fullStr Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title_full_unstemmed Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title_short Infertility and risk of breast cancer in men: a national case–control study in England and Wales
title_sort infertility and risk of breast cancer in men: a national case–control study in england and wales
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112475/
https://www.ncbi.nlm.nih.gov/pubmed/35578306
http://dx.doi.org/10.1186/s13058-022-01517-z
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