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Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

BACKGROUND: Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space is spanned. We built a high-throughput platf...

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Detalles Bibliográficos
Autores principales:	Koch, Philipp, Schmitt, Steven, Heynisch, Alexander, Gumpinger, Anja, Wüthrich, Irene, Gysin, Marina, Shcherbakov, Dimitri, Hobbie, Sven N., Panke, Sven, Held, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112550/ https://www.ncbi.nlm.nih.gov/pubmed/35578204 http://dx.doi.org/10.1186/s12915-022-01304-4

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