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Evaluation of health-related quality of life and influencing factors in patients with Crohn disease

OBJECTIVE: We assessed levels of anxiety and depression in patients with Crohn disease (CD) to identify predictors of health-related quality of life (HRQOL). METHODS: In this case-control study, we enrolled 50 adult patients with CD and 50 matched, healthy controls. All participants completed self-a...

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Autores principales: Gao, Nan, Qiao, Zhenguo, Yan, Su, Zhu, Lanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112784/
https://www.ncbi.nlm.nih.gov/pubmed/35570676
http://dx.doi.org/10.1177/03000605221098868
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author Gao, Nan
Qiao, Zhenguo
Yan, Su
Zhu, Lanxiang
author_facet Gao, Nan
Qiao, Zhenguo
Yan, Su
Zhu, Lanxiang
author_sort Gao, Nan
collection PubMed
description OBJECTIVE: We assessed levels of anxiety and depression in patients with Crohn disease (CD) to identify predictors of health-related quality of life (HRQOL). METHODS: In this case-control study, we enrolled 50 adult patients with CD and 50 matched, healthy controls. All participants completed self-administered questionnaires including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Short Form-36 Health Survey (SF-36), and Short Inflammatory Bowel Disease Questionnaire (IBDQ, patients only). We analyzed the relationship between HRQOL and influencing factors. RESULTS: Mean total scores on the SAS, SDS, and SF-36 were significantly different between patients and controls. IBDQ scores among patients in the active phase of CD were significantly lower than those in remission phase. SF-36 scores were significantly lower in patients with CD compared with healthy controls. SF-36 scores among patients with active CD were significantly lower than scores among those in remission, and SF-36 scores in patients without complications were significantly higher than in those with complications. SF-36 scores in patients with good nutritional status were also significantly higher than scores in malnourished patients with CD. CONCLUSIONS: Depression, anxiety, disease activity, complications, and nutritional status were predictive factors of decreased HRQOL in patients with CD.
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spelling pubmed-91127842022-05-18 Evaluation of health-related quality of life and influencing factors in patients with Crohn disease Gao, Nan Qiao, Zhenguo Yan, Su Zhu, Lanxiang J Int Med Res Prospective Clinical Research Report OBJECTIVE: We assessed levels of anxiety and depression in patients with Crohn disease (CD) to identify predictors of health-related quality of life (HRQOL). METHODS: In this case-control study, we enrolled 50 adult patients with CD and 50 matched, healthy controls. All participants completed self-administered questionnaires including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Short Form-36 Health Survey (SF-36), and Short Inflammatory Bowel Disease Questionnaire (IBDQ, patients only). We analyzed the relationship between HRQOL and influencing factors. RESULTS: Mean total scores on the SAS, SDS, and SF-36 were significantly different between patients and controls. IBDQ scores among patients in the active phase of CD were significantly lower than those in remission phase. SF-36 scores were significantly lower in patients with CD compared with healthy controls. SF-36 scores among patients with active CD were significantly lower than scores among those in remission, and SF-36 scores in patients without complications were significantly higher than in those with complications. SF-36 scores in patients with good nutritional status were also significantly higher than scores in malnourished patients with CD. CONCLUSIONS: Depression, anxiety, disease activity, complications, and nutritional status were predictive factors of decreased HRQOL in patients with CD. SAGE Publications 2022-05-14 /pmc/articles/PMC9112784/ /pubmed/35570676 http://dx.doi.org/10.1177/03000605221098868 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Gao, Nan
Qiao, Zhenguo
Yan, Su
Zhu, Lanxiang
Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title_full Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title_fullStr Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title_full_unstemmed Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title_short Evaluation of health-related quality of life and influencing factors in patients with Crohn disease
title_sort evaluation of health-related quality of life and influencing factors in patients with crohn disease
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112784/
https://www.ncbi.nlm.nih.gov/pubmed/35570676
http://dx.doi.org/10.1177/03000605221098868
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