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Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis

Chemical exchange saturation transfer (CEST) is one of the molecular magnetic resonance imaging (MRI) techniques that indirectly measures low-concentration metabolite or free protein signals that are difficult to detect by conventional MRI techniques. We applied CEST to Alzheimer’s disease (AD) and...

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Autores principales: Liu, Yixuan, Li, Jie, Ji, Hongfei, Zhuang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112835/
https://www.ncbi.nlm.nih.gov/pubmed/35592256
http://dx.doi.org/10.3389/fnins.2022.838157
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author Liu, Yixuan
Li, Jie
Ji, Hongfei
Zhuang, Jie
author_facet Liu, Yixuan
Li, Jie
Ji, Hongfei
Zhuang, Jie
author_sort Liu, Yixuan
collection PubMed
description Chemical exchange saturation transfer (CEST) is one of the molecular magnetic resonance imaging (MRI) techniques that indirectly measures low-concentration metabolite or free protein signals that are difficult to detect by conventional MRI techniques. We applied CEST to Alzheimer’s disease (AD) and analyzed both region of interest (ROI) and pixel dimensions. Through the analysis of the ROI dimension, we found that the content of glutamate in the brains of AD mice was higher than that of normal mice of the same age. In the pixel-dimensional analysis, we obtained a map of the distribution of glutamate in the mouse brain. According to the experimental data of this study, we designed an algorithm framework based on data migration and used Resnet neural network to classify the glutamate distribution images of AD mice, with an accuracy rate of 75.6%. We evaluate the possibility of glutamate imaging as a biomarker for AD detection for the first time, with important implications for the detection and treatment of AD.
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spelling pubmed-91128352022-05-18 Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis Liu, Yixuan Li, Jie Ji, Hongfei Zhuang, Jie Front Neurosci Neuroscience Chemical exchange saturation transfer (CEST) is one of the molecular magnetic resonance imaging (MRI) techniques that indirectly measures low-concentration metabolite or free protein signals that are difficult to detect by conventional MRI techniques. We applied CEST to Alzheimer’s disease (AD) and analyzed both region of interest (ROI) and pixel dimensions. Through the analysis of the ROI dimension, we found that the content of glutamate in the brains of AD mice was higher than that of normal mice of the same age. In the pixel-dimensional analysis, we obtained a map of the distribution of glutamate in the mouse brain. According to the experimental data of this study, we designed an algorithm framework based on data migration and used Resnet neural network to classify the glutamate distribution images of AD mice, with an accuracy rate of 75.6%. We evaluate the possibility of glutamate imaging as a biomarker for AD detection for the first time, with important implications for the detection and treatment of AD. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9112835/ /pubmed/35592256 http://dx.doi.org/10.3389/fnins.2022.838157 Text en Copyright © 2022 Liu, Li, Ji and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Yixuan
Li, Jie
Ji, Hongfei
Zhuang, Jie
Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title_full Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title_fullStr Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title_full_unstemmed Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title_short Comparisons of Glutamate in the Brains of Alzheimer’s Disease Mice Under Chemical Exchange Saturation Transfer Imaging Based on Machine Learning Analysis
title_sort comparisons of glutamate in the brains of alzheimer’s disease mice under chemical exchange saturation transfer imaging based on machine learning analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112835/
https://www.ncbi.nlm.nih.gov/pubmed/35592256
http://dx.doi.org/10.3389/fnins.2022.838157
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