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Preclinical Data on the Gardnerella-Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance

Antibiotics are the mainstay of therapy for bacterial vaginosis (BV). However, the rate of treatment failure in patients with recurrent BV is about 50%. Herein, we investigated potential mechanisms of therapy failure, including the propensity of resistance formation and biofilm activity of metronida...

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Detalles Bibliográficos
Autores principales:	Landlinger, Christine, Oberbauer, Vera, Podpera Tisakova, Lenka, Schwebs, Timo, Berdaguer, Rocío, Van Simaey, Leen, Vaneechoutte, Mario, Corsini, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112913/ https://www.ncbi.nlm.nih.gov/pubmed/35416708 http://dx.doi.org/10.1128/aac.02319-21

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