A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae

The continued emergence of Neisseria gonorrhoeae isolates which are resistant to first-line antibiotics has reinvigorated interest in alternative therapies such as expanded use of gentamicin (Gen). We hypothesized that expanded use of Gen promotes emergence of gonococci with clinical resistance to t...

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Detalles Bibliográficos
Autores principales: Holley, Concerta L., Dhulipala, Vijaya, Balthazar, Jacqueline T., Le Van, Adriana, Begum, Afrin A., Chen, Shao-Chun, Read, Timothy D., Matoga, Mitch, Hoffman, Irving F., Golparian, Daniel, Unemo, Magnus, Jerse, Ann E., Shafer, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112995/
https://www.ncbi.nlm.nih.gov/pubmed/35465683
http://dx.doi.org/10.1128/aac.00251-22

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