Cargando…
Biophysical Insight into the SARS-CoV2 Spike–ACE2 Interaction and Its Modulation by Hepcidin through a Multifaceted Computational Approach
[Image: see text] At the center of the SARS-CoV2 infection, the spike protein and its interaction with the human receptor ACE2 play a central role in the molecular machinery of SARS-CoV2 infection of human cells. Vaccine therapies are a valuable barrier to the worst effects of the virus and to its d...
Autores principales: | Hadi-Alijanvand, Hamid, Di Paola, Luisa, Hu, Guang, Leitner, David M., Verkhivker, Gennady M., Sun, Peixin, Poudel, Humanath, Giuliani, Alessandro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113007/ https://www.ncbi.nlm.nih.gov/pubmed/35600142 http://dx.doi.org/10.1021/acsomega.2c00154 |
Ejemplares similares
-
A Statistical Journey through the Topological Determinants of the β2 Adrenergic Receptor Dynamics
por: Di Paola, Luisa, et al.
Publicado: (2022) -
Biophysical properties of the isolated spike protein binding helix of human ACE2
por: Das, Anirban, et al.
Publicado: (2021) -
Coevolution, Dynamics and Allostery Conspire in Shaping Cooperative Binding and Signal Transmission of the SARS-CoV-2 Spike Protein with Human Angiotensin-Converting Enzyme 2
por: Verkhivker, Gennady
Publicado: (2020) -
Allosteric Determinants of the SARS-CoV-2 Spike Protein Binding with Nanobodies: Examining Mechanisms of Mutational Escape and Sensitivity of the Omicron Variant
por: Verkhivker, Gennady
Publicado: (2022) -
Structural and Computational Studies of the SARS-CoV-2 Spike Protein Binding Mechanisms with Nanobodies: From Structure and Dynamics to Avidity-Driven Nanobody Engineering
por: Verkhivker, Gennady
Publicado: (2022)